SCHEMBL5481908

SCHEMBL5481908

Cc1ccc(C[Si](Cl)(Cl)Cl)c(Cl)c1Cl

nearest known ligand 0.30

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CLIC1 O00299 1/20 0.30
CXCL8 P10145 1/20 0.30
CLCN2 P51788 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13258722 0.77 ALDH1A1 (0.33) CLIC1CXCL8CLCN2ALDH1A1LMNA
SCHEMBL9124867 0.75 CTRC (0.40) CLIC1CXCL8CLCN2ALDH1A1LMNA
SCHEMBL2361510 0.73 ALDH1A1 (0.35) CLIC1CXCL8CLCN2ALDH1A1LMNA
SCHEMBL5490607 0.72
SCHEMBL5482845 0.72 HDAC3 (0.40)
SCHEMBL5481506 0.72
SCHEMBL7614522 0.72 CYP3A4 (0.43) ALDH1A1LMNA
SCHEMBL29403294 0.72 CYP3A4 (0.41) ALDH1A1LMNA
SCHEMBL477584 0.72 CYP3A4 (0.41) ALDH1A1LMNA
SCHEMBL9642662 0.70 CHRM2 (0.34) CLIC1CXCL8CLCN2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed