Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CDC42 | P60953 | 1/20 | 0.43 |
| ▸ | RAC1 | P63000 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.40 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5483297 | 0.89 | KDM4E (0.44) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL7355965 | 0.78 | LTA4H (0.43) | PTGS2MAPTL3MBTL1CYP26A1 | |
| SCHEMBL2527651 | 0.75 | ALDH1A1 (0.47) | CYP1A2LMNAMAPTCYP2C9TDP1 | |
| SCHEMBL9298556 | 0.73 | NPSR1 (0.44) | TSHRCYP1A2LMNAMAPTCYP2C9 | |
| SCHEMBL2660701 | 0.73 | LTA4H (0.43) | PTGS2LMNAL3MBTL1CYP26A1ALOX5 | |
| SCHEMBL8110660 | 0.71 | CES2 (0.39) | AKR1C3AKR1C2 | |
| SCHEMBL3735338 | 0.71 | NPSR1 (0.44) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL8110197 | 0.71 | CHRNA1 (0.47) | — | |
| SCHEMBL4828425 | 0.70 | AKR1C3 (0.54) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL8111034 | 0.70 | SLC6A2 (0.48) | TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233769-B1 | Imidazole derivatives | SMITHKLINE BEECHAM PLC (GB) | 2007-12-26 | — | — | EP | disclosed |
| US-7189745-B1 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-13 | — | — | US | disclosed |
| US-20070010534-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2007-01-11 | — | — | US | disclosed |
| EP-1233769-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2004-12-29 | — | — | EP | disclosed |
| EP-1233769-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001037835-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM PLC. (GB) | 2001-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010534-A1 | NOVEL COMPOUNDS | TIE1, TEK, VEGFA | AKR1C3 992/4885AKR1C2 854/4885PTGS2 197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.