Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 5/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | PPM1D | O15297 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4179196 | 0.94 | TACR2 (0.44) | NPY5RUTS2RTACR2RENCTSB | |
| SCHEMBL4192205 | 0.91 | TRPV4 (0.47) | KMT2AMEN1CCR1TACR2REN | |
| SCHEMBL4178416 | 0.89 | UTS2R (0.51) | KMT2AMEN1NPY5RCCR1UTS2R | |
| SCHEMBL4175710 | 0.88 | CTSK (0.44) | KMT2AMEN1NPY5RCCR1UTS2R | |
| SCHEMBL4188403 | 0.88 | MAPK1 (0.49) | KMT2AMEN1NPY5RCCR1UTS2R | |
| SCHEMBL4181435 | 0.87 | CCR1 (0.46) | KMT2AMEN1NPY5RCCR1UTS2R | |
| SCHEMBL4181213 | 0.86 | CTSL (0.50) | KMT2AMEN1MMP1MMP2MMP3 | |
| SCHEMBL4191791 | 0.86 | CTSB (0.42) | UTS2RTACR2RENCTSBCTSS | |
| SCHEMBL4180771 | 0.84 | CCR1 (0.47) | KMT2AMEN1NPY5RCCR1UTS2R | |
| SCHEMBL4194752 | 0.83 | CTSK (0.51) | UTS2RTACR2CTSBCTSSMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869026-A1 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105475-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |