Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 7/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1544409 | 0.72 | ANO1 (0.42) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4944624 | 0.64 | RAB9A (0.53) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20021736 | 0.63 | ALDH1A1 (0.55) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1544537 | 0.62 | ANO1 (0.44) | ALDH1A1TSHRSMN1; SMN2KMT2APKM | |
| SCHEMBL1544448 | 0.61 | ALDH1A1 (0.52) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL15983758 | 0.60 | ALDH1A1 (0.65) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1544695 | 0.60 | MEN1 (0.59) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1544692 | 0.60 | KCNH2 (0.41) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5542199 | 0.60 | HTR3E (0.40) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL1544335 | 0.59 | MEN1 (0.58) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070179188-A1 | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179188-A1 | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists | GRM5, GRIK5, GRM2 | ALDH1A1 4066/4885TSHR 847/4885SMN1; SMN2 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.