SCHEMBL548288

SCHEMBL548288

O=Cc1oc2ccc(C(=O)O)c(C=O)c2c(=O)c1-c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.39
▸ KMT2A Q03164 3/20 0.39
▸ HSP90AA1 P07900 1/20 0.39
▸ TBK1 Q9UHD2 2/20 0.36
▸ ERN1 O75460 1/20 0.34
▸ KDM4E B2RXH2 6/20 0.33
▸ ALDH1A1 P00352 3/20 0.33
▸ GPR35 Q9HC97 2/20 0.33
▸ LMNA P02545 2/20 0.33
▸ POLB P06746 1/20 0.33
▸ TTR P02766 1/20 0.33
▸ MAOB P27338 2/20 0.33
▸ CA1 P00915 2/20 0.33
▸ CA12 O43570 1/20 0.33
▸ CA3 P07451 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ CA4 P22748 1/20 0.33
▸ CA6 P23280 1/20 0.33
▸ CA5A P35218 1/20 0.33
▸ CA7 P43166 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL547722 0.87 MEN1 (0.42) MEN1KMT2AHSP90AA1TBK1KDM4E
SCHEMBL548670 0.82 PTPN1 (0.39) MEN1KMT2AHSP90AA1KDM4EALDH1A1
SCHEMBL29793488 0.82 PTPN1 (0.39) MEN1KMT2AHSP90AA1KDM4EALDH1A1
SCHEMBL547708 0.81 MEN1 (0.41) MEN1KMT2AHSP90AA1KDM4EALDH1A1
SCHEMBL548149 0.77 MEN1 (0.42) MEN1KMT2AHSP90AA1KDM4EALDH1A1
SCHEMBL548577 0.75 ALDH1A1 (0.36) MEN1KMT2AHSP90AA1KDM4EALDH1A1
SCHEMBL547866 0.73 CA1 (0.39) MEN1KMT2AHSP90AA1KDM4EALDH1A1
SCHEMBL548717 0.68 MEN1 (0.45) MEN1KMT2AHSP90AA1KDM4EALDH1A1
SCHEMBL11563555 0.66 CA1 (0.49) MEN1KMT2AKDM4EALDH1A1LMNA
SCHEMBL548758 0.66 ERN1 (0.50) ERN1KDM4EALDH1A1LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2080750-B1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL CO (JP) 2020-07-29 — — EP claimed
CN-108008600-B Radiation-sensitive composition 三菱瓦斯化学株式会社 2021-02-09 — — CN disclosed
EP-2080750-B1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL CO (JP) 2020-07-29 — — EP disclosed
US-9897913-B2 Radiation-sensitive composition MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2018-02-20 — — US disclosed
US-20150030980-A1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL CO (JP) 2015-01-29 — — US disclosed
US-8846292-B2 Radiation-sensitive composition MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2014-09-30 — — US disclosed
US-20120171379-A1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2012-07-05 — — US disclosed
US-8110334-B2 Radiation-sensitive composition MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2012-02-07 — — US disclosed
US-20100047709-A1 RADIATION-SENSITIVE COMPOSITION MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2010-02-25 — — US disclosed
EP-2080750-A1 RADIATION-SENSITIVE COMPOSITION Mitsubishi Gas Chemical Company, Inc. (JP) 2009-07-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120171379-A1 RADIATION-SENSITIVE COMPOSITION PARG, RAD51, SRMS MEN1 1441/4885KMT2A 1479/4885HSP90AA1 1378/4885
US-20100047709-A1 RADIATION-SENSITIVE COMPOSITION C1S, C9, RAD51 MEN1 1910/4885KMT2A 645/4885HSP90AA1 1285/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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