Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.40 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | PRKACG | P22612 | 2/20 | 0.38 |
| ▸ | PRKACB | P22694 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5469934 | 0.82 | CHEK1 (0.39) | CHEK1 | |
| SCHEMBL5475725 | 0.81 | CHEK1 (0.45) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL5470898 | 0.81 | CHEK1 (0.48) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL5795592 | 0.79 | ADORA1 (0.46) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL5478073 | 0.77 | CHEK1 (0.63) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL5469037 | 0.73 | CHEK1 (0.66) | KDM4EALDH1A1CHEK1 | |
| SCHEMBL14492324 | 0.73 | CHEK1 (0.47) | KDM4EALDH1A1PDE1APDE1BPDE3B | |
| SCHEMBL10743293 | 0.73 | MTNR1B (0.42) | KDM4EALDH1A1PDE1APDE1BPDE3B | |
| SCHEMBL5469679 | 0.72 | MAOA (0.44) | ALDH1A1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL8129340 | 0.66 | KDM4E (0.49) | KDM4EALDH1A1PDE1APDE1BPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | US | claimed |
| JP-2006520397-A | — | — | 2006-09-07 | — | — | JP | claimed |
| EP-1613625-A1 | NOVEL FUSED TRIAZOLONES AND THE USES THEREOF | AstraZeneca AB (SE) | 2006-01-11 | — | — | EP | claimed |
| WO-2004081008-A1 | NOVEL FUSED TRIAZOLONES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | TP53, BRCA1, KLK3 | KDM4E 3368/4885ALDH1A1 1270/4885PDE1A 3278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.