Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.72 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11037564 | 0.87 | HSD17B10 (0.77) | HSD17B10ADORA2AHTTADRA2AKDM4E | |
| SCHEMBL5483517 | 0.79 | ADORA2A (0.60) | HSD17B10ADORA2AHTTADRA2AKDM4E | |
| SCHEMBL7011406 | 0.75 | ADORA2A (0.70) | HSD17B10ADORA2AHTTADRA2AKDM4E | |
| SCHEMBL8974906 | 0.75 | HSD17B10 (0.68) | HSD17B10ADORA2AHTTADRA2AKDM4E | |
| SCHEMBL11008493 | 0.74 | HTT (0.59) | HSD17B10ADORA2AHTTADRA2AKDM4E | |
| SCHEMBL8299115 | 0.74 | KDM4E (0.80) | HSD17B10ADORA2AHTTADRA2AKDM4E | |
| SCHEMBL16479797 | 0.73 | ALDH1A1 (0.64) | HSD17B10ADORA2AHTTADRA2AKDM4E | |
| SCHEMBL12072170 | 0.73 | ADORA2A (0.53) | HSD17B10ADORA2AHTTADRA2AKDM4E | |
| SCHEMBL5483521 | 0.72 | KDM4E (0.64) | HSD17B10ADORA2AHTTADRA2AKDM4E | |
| SCHEMBL5321147 | 0.72 | ADORA1 (0.77) | ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287738-A1 | Substituted Cyanopyridines as protein kinase inhibitors | WYETH | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287738-A1 | Substituted Cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K6 | HSD17B10 4631/4885ADORA2A 1009/4885HTT 4209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.