Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | BLK | P51451 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5483819 | 1.00 | FLT3 (0.37) | FLT3HRH4HRH3CHEK1CHRM3 | |
| SCHEMBL5479125 | 0.94 | KHK (0.37) | FLT3HRH4CHEK1CCNA2CDK2 | |
| SCHEMBL5479121 | 0.94 | KHK (0.37) | FLT3HRH4CHEK1CCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL5481009 | 0.86 | SGK1 (0.45) | FLT3HRH4HRH3CHEK1CHRM3 | |
| Trifluoroacetic Acid SCHEMBL5481008 | 0.86 | SGK1 (0.45) | FLT3HRH4HRH3CHEK1CHRM3 | |
| SCHEMBL5483836 | 0.85 | CYP11B2 (0.40) | FLT3TYRO3MERTKGAS6 | |
| SCHEMBL5483833 | 0.85 | CYP11B2 (0.40) | FLT3TYRO3MERTKGAS6 | |
| SCHEMBL8294128 | 0.85 | CYP11B2 (0.40) | FLT3TYRO3MERTKGAS6 | |
| SCHEMBL8292579 | 0.83 | GRIN2B (0.38) | KHK | |
| SCHEMBL14431020 | 0.82 | GRIN2B (0.41) | CCNA2CDK2MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185104-A1 | Benzoxazole acetonitriles | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2007-08-09 | — | — | US | disclosed |
| EP-1668004-A1 | BENZOXAZOLE ACETONITRILES | Applied Research Systems ARS Holding N.V. (AN) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005026159-A1 | BENZOXAZOLE ACETONITRILES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185104-A1 | Benzoxazole acetonitriles | PKD1, PC, GPR119 | FLT3 1567/4885HRH4 1758/4885HRH3 1293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.