Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 2/20 | 0.33 |
| ▸ | FNTB | P49356 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5484026 | 0.80 | MAPK1 (0.47) | MAPK1ATMRAB9A | |
| SCHEMBL4185666 | 0.78 | ATM (0.47) | MAPK1KDM4EATMCTDSP1TDP1 | |
| SCHEMBL5487435 | 0.77 | CTSL (0.40) | MAPK1KDM4EATMRAB9AKMT2A | |
| SCHEMBL4175983 | 0.77 | KDM4E (0.43) | KDM4EATMRAB9AACLYTRPV4 | |
| SCHEMBL4171002 | 0.77 | CTSL (0.49) | CTSS | |
| SCHEMBL4188373 | 0.76 | CTSS (0.39) | MAPK1KDM4EATMRAB9ACTSS | |
| SCHEMBL4188234 | 0.76 | CTSL (0.44) | KDM4EATMRAB9AKMT2ATSHR | |
| SCHEMBL4188233 | 0.76 | CTSL (0.44) | KDM4EATMRAB9AKMT2ATSHR | |
| SCHEMBL4183292 | 0.75 | USP30 (0.39) | KDM4EATMRAB9AKMT2ACTSS | |
| Hydrochloric Acid SCHEMBL4189192 | 0.75 | ATM (0.40) | MAPK1KDM4EATMCTDSP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869026-A1 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105475-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |