Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 7/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5482709 | 0.92 | LTA4H (0.41) | GRIA2PGRGRIN1GRIN2BSLC6A4 | |
| SCHEMBL5484649 | 0.90 | GRIA2 (0.51) | GRIA2PGRABL1 | |
| SCHEMBL5621041 | 0.90 | GRIA2 (0.40) | GRIA2PGRF2F10POLB | |
| SCHEMBL5477040 | 0.85 | GRIA2 (0.39) | GRIA2POLB | |
| SCHEMBL5479955 | 0.82 | GRIA2 (0.39) | GRIA2POLBSLC6A4 | |
| SCHEMBL5483529 | 0.81 | GRIA2 (0.41) | GRIA2F2F10DRD2 | |
| SCHEMBL5482710 | 0.81 | GRIA2 (0.54) | GRIA2PGR | |
| SCHEMBL5620019 | 0.81 | GRIA2 (0.39) | GRIA2PGRCACNA1HCACNA1BSLC6A4 | |
| SCHEMBL5621042 | 0.79 | GRIA2 (0.53) | GRIA2PGRDRD2DRD4DRD3 | |
| SCHEMBL5486900 | 0.79 | GRIA2 (0.40) | GRIA2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655030-B1 | Benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | SERVIER LAB (FR) | 2007-12-19 | — | — | EP | disclosed |
| US-20070270415-A1 | Benzothiadiazine compounds | LESLABORATOIRES SERVIER (FR) | 2007-11-22 | — | — | US | disclosed |
| US-7268130-B2 | Benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2007-09-11 | — | — | US | disclosed |
| EP-1655030-A1 | Benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | Les Laboratoires Servier (FR) | 2006-05-10 | — | — | EP | disclosed |
| US-20060094712-A1 | New benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2006-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270415-A1 | Benzothiadiazine compounds | SLC1A1, SLC1A2, SULT2A1 | GRIA2 47/4885PGR 2853/4885F2 2588/4885 |
| US-20060094712-A1 | New benzothiadiazine compounds | SLC1A1, SLC1A2, GABRA5 | GRIA2 36/4885PGR 3335/4885F2 3552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.