Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 9/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15904697 | 0.69 | KDM4E (0.45) | KDM4EUSP2HPGDNPSR1HSD17B10 | |
| SCHEMBL16034931 | 0.65 | CCR2 (0.30) | — | |
| SCHEMBL5484681 | 0.63 | KDM4E (0.36) | KDM4EUSP2HPGDNPSR1HSD17B10 | |
| SCHEMBL2435778 | 0.62 | APLNR (0.46) | KDM4ENPSR1CYP2C19LMNATDP1 | |
| SCHEMBL2435779 | 0.62 | APLNR (0.46) | KDM4ENPSR1CYP2C19LMNATDP1 | |
| SCHEMBL2435781 | 0.62 | APLNR (0.46) | KDM4ENPSR1CYP2C19LMNATDP1 | |
| SCHEMBL15903964 | 0.61 | NOTUM (0.50) | KDM4ECYP2C19NOTUM | |
| SCHEMBL1222301 | 0.60 | NOTUM (0.79) | KDM4ECYP2C19NOTUMPOLBAPAF1 | |
| SCHEMBL2479136 | 0.60 | NOTUM (0.33) | KDM4EUSP2HPGDNPSR1HSD17B10 | |
| SCHEMBL5801907 | 0.60 | NOTUM (0.57) | KDM4EUSP2HPGDNPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314113-B2 | Substituted dihydroquinazolines II | AICURIS GMBH & CO. KG (DE) | 2012-11-20 | — | — | US | disclosed |
| US-20070281953-A1 | Substituted Dihydroquinazolines II | BAYER HEALTHCARE AG (DE) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281953-A1 | Substituted Dihydroquinazolines II | EIF2AK2, QDPR, IRF3 | KDM4E 2391/4885USP2 3435/4885HPGD 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.