Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30039348 | 1.00 | KDM4E (0.53) | KDM4EALDH1A1HPGDITKNQO2 | |
| SCHEMBL594346 | 0.87 | KDM4E (0.55) | KDM4EALDH1A1HPGDITKNQO2 | |
| SCHEMBL15505899 | 0.81 | MCHR1 (0.36) | KDM4EALDH1A1HPGDITKMEN1 | |
| SCHEMBL28369687 | 0.80 | CHEK1 (0.55) | KDM4EALDH1A1HPGDITKNQO2 | |
| SCHEMBL29254453 | 0.80 | ATP4A (0.41) | KDM4EALDH1A1HPGDABL1RAD52 | |
| SCHEMBL30548013 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1HPGDITKNQO2 | |
| SCHEMBL20674039 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1HPGDITKNQO2 | |
| SCHEMBL7357858 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1HPGDITKNQO2 | |
| SCHEMBL5746944 | 0.77 | CHEK1 (0.46) | KDM4EALDH1A1POLBMAPTKMT2A | |
| SCHEMBL24210652 | 0.76 | CHEK1 (0.33) | KDM4EALDH1A1HPGDITKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330250-B1 | HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING | BOEHRINGER INGELHEIM INT (DE) | 2025-02-19 | — | — | EP | disclosed |
| CN-118546123-A | Heterocyclic compounds capable of activating STING | 勃林格殷格翰国际有限公司 | 2024-08-27 | — | — | CN | disclosed |
| US-12065427-B2 | Heterocyclic compounds capable of activating STING | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-08-20 | — | — | US | disclosed |
| US-20240270718-A1 | HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING | BOEHRINGER INGELHEIM INT (DE) | 2024-08-15 | — | — | US | disclosed |
| CN-117255784-A | Heterocyclic compounds capable of activating STING | 勃林格殷格翰国际有限公司 | 2023-12-19 | — | — | CN | disclosed |
| US-20220388986-A1 | HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-12-08 | — | — | US | disclosed |
| WO-2022092084-A1 | FUSED HETEROCYCLE DERIVATIVE AND HERBICIDE CONTAINING SAME AS ACTIVE INGREDIENT | クミアイ化学工業株式会社 | 2022-05-05 | — | — | WO | disclosed |
| WO-2022078971-A1 | NOVEL COMPOUNDS | AC IMMUNE SA (CH) | 2022-04-21 | — | — | WO | disclosed |
| US-7217724-B2 | Indole, indazole, and benzazole derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-05-15 | — | — | US | disclosed |
| US-20060063762-A1 | Indole indazole and benzazole derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2006-03-23 | — | — | US | disclosed |
| EP-1514869-A1 | INDOLE, INDAZOLE, AND BENZAZOLE DERIVATIVE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220388986-A1 | HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING | STING1, IRF3, CGAS | KDM4E 3272/4885ALDH1A1 3754/4885HPGD 415/4885 |
| US-20060063762-A1 | Indole indazole and benzazole derivative | ADRB3, ADRA2C, ADRB2 | KDM4E 1432/4885ALDH1A1 847/4885HPGD 3173/4885 |
| US-20240270718-A1 | HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING | STING1, IRF3, CGAS | KDM4E 3272/4885ALDH1A1 3754/4885HPGD 415/4885 |
| US-12065427-B2 | Heterocyclic compounds capable of activating STING | STING1, IRF3, CGAS | KDM4E 3272/4885ALDH1A1 3754/4885HPGD 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.