Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941327 | 0.99 | HPGD (0.43) | HPGDLMNAMAPK1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6943653 | 0.88 | HPGD (0.36) | HPGDLMNAMAPK1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6573781 | 0.87 | MAPK1 (0.40) | HPGDLMNAMAPK1HTTALDH1A1 | |
| SCHEMBL6944219 | 0.86 | HPGD (0.37) | HPGDLMNAMAPK1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6942108 | 0.86 | HPGD (0.35) | HPGDLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL6572970 | 0.85 | HPGD (0.41) | HPGDLMNAMAPK1HTTALDH1A1 | |
| SCHEMBL6946387 | 0.84 | HPGD (0.36) | HPGDLMNAMAPK1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6944858 | 0.84 | ALDH1A1 (0.36) | HPGDLMNAMAPK1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6940892 | 0.84 | HPGD (0.43) | HPGDLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL6946291 | 0.83 | ALDH1A1 (0.36) | HPGDLMNAMAPK1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066022-B1 | COMPOSITIONS FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC COUPLER, NOVEL CATIONIC COUPLERS, THEIR USE FOR OXIDATION DYEING AND DYEING METHODS | OREAL (FR) | 2003-10-22 | — | — | EP | claimed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | claimed |
| US-20070226917-A1 | Hair Dye Agent Comprising Organosilicon Copolymers with Amino Groups and Polyoxyalkylene Groups and Use Thereof | HENKEL KGAA (DE) | 2007-10-04 | — | — | US | disclosed |
| US-7179303-B2 | Active ingredient combinations for hair-dyeing agents | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2007-02-20 | — | — | US | disclosed |
| US-20040133996-A1 | Active ingredient combinations for hair-dyeing agents | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2004-07-15 | — | — | US | disclosed |
| US-20040064901-A1 | Enzymatic coloring agents | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2004-04-08 | — | — | US | disclosed |
| US-6544298-B1 | Dyeing human hair using coupler | L'OREAL (FR) | 2003-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040133996-A1 | Active ingredient combinations for hair-dyeing agents | KRT18, COL1A1, MKI67 | HPGD 388/4885LMNA 114/4885MAPK1 166/4885 |
| US-20040064901-A1 | Enzymatic coloring agents | GLA, HEXA, HSD17B14 | HPGD 1449/4885LMNA 1279/4885MAPK1 2029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.