Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739564 | 0.85 | CYP3A4 (0.42) | CYP3A4SMN1; SMN2ALPLALPIMAPT | |
| SCHEMBL5753191 | 0.83 | CYP3A4 (0.43) | CYP3A4ALPLALPIMAPTMEN1 | |
| SCHEMBL2895698 | 0.82 | CHRNB2 (0.41) | DRD2DRD3CYP3A4ALPLALPI | |
| SCHEMBL2895530 | 0.82 | CYP3A4 (0.46) | DRD2DRD3CYP3A4ALPLALPI | |
| SCHEMBL2891581 | 0.80 | CYP3A4 (0.47) | CYP3A4SMN1; SMN2ALPLALPIMAPT | |
| SCHEMBL2893164 | 0.80 | GAA (0.36) | CYP3A4SMN1; SMN2ALPLALPIMEN1 | |
| SCHEMBL2898303 | 0.80 | CHRNB2 (0.45) | DRD2DRD3SMN1; SMN2MAPTMEN1 | |
| SCHEMBL5740751 | 0.78 | GRM5 (0.34) | SMN1; SMN2MAPTMEN1KMT2APOLB | |
| SCHEMBL2893049 | 0.78 | SMN1; SMN2 (0.41) | CYP3A4SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL2893692 | 0.77 | ALPL (0.41) | CYP3A4ALPLALPIMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197549-A1 | Tetrazole compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2007-08-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197549-A1 | Tetrazole compounds and their use as metabotropic glutamate receptor antagonists | GRM1, GRM3, GRM4 | DRD2 419/4885DRD3 374/4885CYP3A4 960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.