Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2898010 | 0.83 | SMN1; SMN2 (0.34) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2893049 | 0.83 | SMN1; SMN2 (0.41) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2893427 | 0.81 | ALDH1A1 (0.37) | GRM5MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2889757 | 0.81 | GRM5 (0.46) | GRM5MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5485045 | 0.78 | DRD2 (0.34) | MEN1KMT2ASMN1; SMN2MAPK1MAPT | |
| SCHEMBL2893150 | 0.76 | LMNA (0.40) | GRM5MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2895763 | 0.75 | MAPK1 (0.43) | GRM5MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL2892844 | 0.75 | GRM5 (0.34) | GRM5MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5752463 | 0.75 | GRM5 (0.53) | GRM5MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2897747 | 0.74 | SMN1; SMN2 (0.32) | GRM5MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |