Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19895802 | 0.79 | PSMD14 (0.42) | — | |
| SCHEMBL3954797 | 0.79 | PSMB8 (0.37) | PSMB8LMNAPDE10ANPC1RAB9A | |
| SCHEMBL10984833 | 0.76 | LMNA (0.43) | PSMB8LMNAPDE10ANPC1RAB9A | |
| SCHEMBL5077318 | 0.76 | ELANE (0.44) | PSMB8LMNAPDE10ANPC1RAB9A | |
| SCHEMBL3656154 | 0.76 | DAGLA (0.40) | LMNANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL5535607 | 0.76 | CYP1A2 (0.36) | PSMB8LMNAPDE10ANPC1RAB9A | |
| SCHEMBL9390262 | 0.76 | ELANE (0.39) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL1121652 | 0.76 | — | — | |
| SCHEMBL9563347 | 0.76 | PSMB8 (0.35) | PSMB8LMNAPDE10ANPC1RAB9A | |
| SCHEMBL31147003 | 0.76 | PSMB8 (0.35) | PSMB8LMNAPDE10ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106478537-B | A kind of preparation method of [2- [(the chloro- benzoxazoles -2- base of 5-) (3- oxo butyl) amino] ethyl] t-butyl carbamate | 上海再启生物技术有限公司 | 2019-01-15 | — | — | CN | claimed |
| CN-106928131-A | A kind of preparation method of haloxyfop-r-methyl | 江苏凯晨化工有限公司 | 2017-07-07 | — | — | CN | claimed |
| CN-106478537-A | A kind of preparation method of [2 [(5 chlorobenzene diozaiole, 2 base) (3 oxo butyl) amino] ethyl] t-butyl carbamate | 上海再启生物技术有限公司 | 2017-03-08 | — | — | CN | claimed |
| CN-102925138-B | II-VI type long-life quantum dot and preparation method thereof | UNIV DALIAN TECH | 2015-07-22 | — | — | CN | claimed |
| EP-3735411-B1 | 1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER`S DISEASE | AC IMMUNE SA (CH) | 2024-07-10 | — | — | EP | disclosed |
| EP-3735411-B1 | 1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER`S DISEASE | AC IMMUNE SA (CH) | 2024-07-10 | — | — | EP | disclosed |
| CN-115124485-B | Sulfoxide-containing benzoxazole derivative, and preparation method and application thereof | 中国医学科学院药物研究所 | 2023-12-15 | — | — | CN | disclosed |
| US-11814378-B2 | Compounds for the treatment, alleviation or prevention of disorders associated with Tau aggregates | AC IMMUNE SA (CH) | 2023-11-14 | — | — | US | disclosed |
| US-11814378-B2 | Compounds for the treatment, alleviation or prevention of disorders associated with Tau aggregates | AC IMMUNE SA (CH) | 2023-11-14 | — | — | US | disclosed |
| US-20230312878-A1 | RUBBER COMPOSITION AND CROSSLINKED RUBBER MOLDED PRODUCT | SUMITOMO RUBBER INDUSTRIES, LTD. (JP) | 2023-10-05 | — | — | US | disclosed |
| US-20230312878-A1 | RUBBER COMPOSITION AND CROSSLINKED RUBBER MOLDED PRODUCT | SUMITOMO RUBBER INDUSTRIES, LTD. (JP) | 2023-10-05 | — | — | US | disclosed |
| CN-115124485-A | Benzoxazole derivatives containing sulfoxide as well as preparation method and application thereof | 中国医学科学院药物研究所 | 2022-09-30 | — | — | CN | disclosed |
| CN-101880276-A | Diazepan compounds as the replacement of orexin receptor antagonists | MERCK & CO INC | 2010-11-10 | — | — | CN | disclosed |
| CN-101627028-A | Substituted diazepan compounds as orexin receptor antagonists | MERCK & CO INC | 2010-01-13 | — | — | CN | disclosed |
| CN-101307036-A | Method for preparing 2,6-dichloro benzoxazole | YU TONG (CN) | 2008-11-19 | — | — | CN | disclosed |
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |
| CN-1333771-A | Benzoxazole derivative and drug containing the same as active ingredient | MEIJI SEIKA KAISHA (JP) | 2002-01-30 | — | — | CN | disclosed |
| WO-1994006782-A1 | BENZOXAZOLE AND BEZOTHIAZOLE DERIVATIVES | ZENECA LIMITED (GB) | 1994-03-31 | — | — | WO | disclosed |
| WO-1994006783-A1 | BENZOXAZOLE AND BENZOTHIAZOLE DERIVATIVES | ZENECA LIMITED (GB) | 1994-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11814378-B2 | Compounds for the treatment, alleviation or prevention of disorders associated with Tau aggregates | MAPT, MAP1LC3A, TUBB3 | PSMB8 1025/4885LMNA 2017/4885PDE10A 3512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.