Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742335 | 0.82 | LMNA (0.40) | ALDH1A1SMN1; SMN2LMNAKDM4EHTT | |
| SCHEMBL10914343 | 0.79 | TSHR (0.39) | ALDH1A1SMN1; SMN2LMNAMAPK1KDM4E | |
| SCHEMBL10914346 | 0.79 | TSHR (0.39) | ALDH1A1SMN1; SMN2LMNAMAPK1KDM4E | |
| SCHEMBL4390254 | 0.78 | TSHR (0.42) | ALDH1A1SMN1; SMN2LMNAHPGDHTT | |
| SCHEMBL2298630 | 0.75 | TSHR (0.39) | ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL10061896 | 0.72 | MAPT (0.47) | ALDH1A1SMN1; SMN2LMNAPOLBMAPK1 | |
| SCHEMBL27736702 | 0.72 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2LMNAMAPK1KDM4E | |
| SCHEMBL8760108 | 0.72 | MAPT (0.51) | ALDH1A1MAPK1KDM4EMAPTHPGD | |
| SCHEMBL27468094 | 0.72 | MAPT (0.51) | ALDH1A1MAPK1KDM4EMAPTHPGD | |
| SCHEMBL28850127 | 0.72 | TSHR (0.42) | ALDH1A1SMN1; SMN2LMNAMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242059-B1 | NOVEL PRODRUGS FOR ANTIMICROBIAL AMIDINES | UNIV NORTH CAROLINA (US) | 2007-03-21 | — | — | EP | claimed |
| WO-2001062242-A1 | PRODRUGS OF SUBSTITUTED CYCLOPENTANE AND CYCLOPENTENE COMPOUNDS USEFUL AS NEURAMINIDASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2001-08-30 | — | — | WO | disclosed |