Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 11/20 | 0.56 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5487078 | 0.86 | GRIA2 (0.71) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5487068 | 0.86 | GRIA2 (0.53) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5184614 | 0.83 | GRIA2 (0.70) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5183876 | 0.78 | GRIA2 (0.58) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5362165 | 0.72 | GRIA2 (1.00) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL2177681 | 0.71 | GRIA2 (0.70) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5359084 | 0.70 | GRIA2 (0.73) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5355997 | 0.69 | GRIA2 (0.71) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5361134 | 0.69 | GRIA2 (0.83) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5479896 | 0.69 | GRIA2 (0.48) | GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655030-B1 | Benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | SERVIER LAB (FR) | 2007-12-19 | — | — | EP | disclosed |
| US-20070270415-A1 | Benzothiadiazine compounds | LESLABORATOIRES SERVIER (FR) | 2007-11-22 | — | — | US | disclosed |
| US-7268130-B2 | Benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2007-09-11 | — | — | US | disclosed |
| US-7262191-B2 | Benzothiadiazine compounds | LES LABORATORIES SERVIER (FR) | 2007-08-28 | — | — | US | disclosed |
| EP-1655299-A1 | Benzothiadiazine derivatives, process of preparation thereof and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2006-05-10 | — | — | EP | disclosed |
| EP-1655030-A1 | Benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | Les Laboratoires Servier (FR) | 2006-05-10 | — | — | EP | disclosed |
| US-20060094713-A1 | New benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2006-05-04 | — | — | US | disclosed |
| US-20060094712-A1 | New benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2006-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270415-A1 | Benzothiadiazine compounds | SLC1A1, SLC1A2, SULT2A1 | GRIA2 47/4885GRIA1 64/4885GRIA3 84/4885 |
| US-20060094712-A1 | New benzothiadiazine compounds | SLC1A1, SLC1A2, GABRA5 | GRIA2 36/4885GRIA1 48/4885GRIA3 54/4885 |
| US-20060094713-A1 | New benzothiadiazine compounds | SQOR, NDUFS5, GLRX3 | GRIA2 125/4885GRIA1 82/4885GRIA3 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.