Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SLC6A12 | P48065 | 3/20 | 0.33 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.33 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30477996 | 0.78 | HSD11B1 (0.46) | HSD11B1ALDH1A1KDM4EHTTGRM2 | |
| SCHEMBL5810447 | 0.77 | HSD11B1 (0.44) | HSD11B1ALDH1A1KDM4EHTTSLC6A12 | |
| SCHEMBL1592795 | 0.75 | GRIN2D (0.31) | ALDH1A1EPHX2 | |
| SCHEMBL677091 | 0.74 | HSD11B1 (0.33) | HSD11B1ALDH1A1EPHX2 | |
| SCHEMBL28732515 | 0.72 | CD81 (0.35) | THRBCYP2C9NPSR1 | |
| SCHEMBL677864 | 0.71 | KMT2A (0.32) | HSD11B1EPHX2 | |
| SCHEMBL8098594 | 0.71 | HSD11B1 (0.61) | HSD11B1SLC6A12SLC6A11SLC6A13GRM2 | |
| SCHEMBL19151709 | 0.70 | HSD11B1 (0.38) | HSD11B1 | |
| Acrylic Acid SCHEMBL28717241 | 0.70 | NPSR1 (0.34) | THRBCYP2C9EPHX2NPSR1 | |
| SCHEMBL6742682 | 0.69 | THRB (0.36) | HSD11B1ALDH1A1KDM4EHTTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120276600-A1 | Process For Preparing Dipeptidyl Peptidase IV Inhibitors And Intermediates Therefor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-11-01 | — | — | US | disclosed |
| EP-1581487-A4 | METHODS AND COMPOUNDS PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1581487-A2 | METHODS AND COMPOUNDS PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004052850-A2 | METHODS AND COMPOUNDS PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120276600-A1 | Process For Preparing Dipeptidyl Peptidase IV Inhibitors And Intermediates Therefor | DNPEP, DPP4, DPP8 | HSD11B1 1075/4885ALDH1A1 403/4885KDM4E 1415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.