Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27852503 | 0.79 | TSHR (0.39) | ALDH1A1GRIA2SMN1; SMN2USP2KDM4E | |
| SCHEMBL2057187 | 0.79 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2POLBLMNATSHR | |
| SCHEMBL10192138 | 0.78 | ALDH1A1 (0.49) | ALDH1A1APLNRGRIA2POLBLMNA | |
| SCHEMBL12188926 | 0.78 | HPGD (0.47) | ALDH1A1APLNRGRIA2SMN1; SMN2USP2 | |
| SCHEMBL11171556 | 0.76 | SMN1; SMN2 (0.43) | ALDH1A1APLNRGRIA2SMN1; SMN2USP2 | |
| SCHEMBL19563399 | 0.76 | PYCR1 (0.46) | ALDH1A1APLNRGRIA2SMN1; SMN2USP2 | |
| SCHEMBL7230524 | 0.76 | CA1 (0.44) | ALDH1A1APLNRGRIA2SMN1; SMN2USP2 | |
| SCHEMBL14297420 | 0.76 | TSHR (0.50) | ALDH1A1APLNRGRIA2KDM4ETSHR | |
| SCHEMBL8484369 | 0.76 | APLNR (0.42) | ALDH1A1APLNRGRIA2SMN1; SMN2USP2 | |
| SCHEMBL4351827 | 0.76 | MAPT (0.43) | ALDH1A1APLNRGRIA2SMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655030-B1 | Benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | SERVIER LAB (FR) | 2007-12-19 | — | — | EP | disclosed |
| EP-1655030-A1 | Benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | Les Laboratoires Servier (FR) | 2006-05-10 | — | — | EP | disclosed |