SCHEMBL5487907

SCHEMBL5487907

COc1ccc(CC[Si](Cl)(Cl)Cl)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.55
MAOB P27338 2/20 0.50
CALM1 P0DP23 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.49
LMNA P02545 2/20 0.49
ALDH1A1 P00352 1/20 0.49
SIGMAR1 Q99720 1/20 0.48
AOC3 Q16853 1/20 0.48
IDO1 P14902 1/20 0.48
F2RL1 P55085 1/20 0.47
TUBB4A P04350 1/20 0.47
TUBB P07437 1/20 0.47
TUBA3C P0DPH7 1/20 0.47
TUBA1B P68363 1/20 0.47
TUBA4A P68366 1/20 0.47
TUBB4B P68371 1/20 0.47
TUBB3 Q13509 1/20 0.47
TUBB2A Q13885 1/20 0.47
TUBB8 Q3ZCM7 1/20 0.47
TUBA3E Q6PEY2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL395974 0.88 CALM1 (0.56) TAAR1MAOBCALM1SMN1; SMN2ALDH1A1
SCHEMBL5485255 0.85 CALM1 (0.53) TAAR1MAOBCALM1SMN1; SMN2
SCHEMBL6848455 0.82 CA2 (0.38) TAAR1MAOBALDH1A1IDO1KDM4E
SCHEMBL13027474 0.81 TAAR1 (0.57) TAAR1MAOBCALM1SMN1; SMN2LMNA
SCHEMBL769798 0.79 CALM1 (0.44) TAAR1MAOBCALM1SMN1; SMN2ALDH1A1
SCHEMBL834551 0.79 TAAR1 (0.73) TAAR1MAOBCALM1SIGMAR1AOC3
SCHEMBL1533151 0.79 CALM1 (0.55) TAAR1MAOBCALM1SMN1; SMN2ALDH1A1
SCHEMBL297636 0.78 IDO1 (0.52) TAAR1CALM1SMN1; SMN2LMNAALDH1A1
SCHEMBL17656478 0.78 TAAR1 (0.53) TAAR1MAOBCALM1SMN1; SMN2LMNA
SCHEMBL16335308 0.78 TAAR1 (0.53) TAAR1MAOBCALM1SMN1; SMN2SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed
US-5612170-A SILICONE, PHOTO ACID GENERATOR, DISSOLUTION INHIBITOR SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-03-18 US disclosed