Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estradiol Dipropionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 7/20 | 0.70 |
| ▸ | MAPT | P10636 | 8/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.85 |
| ▸ | MEN1 | O00255 | 6/20 | 0.85 |
| ▸ | THRB | P10828 | 1/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.80 |
| ▸ | TP53 | P04637 | 4/20 | 0.80 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.80 |
| ▸ | LMNA | P02545 | 11/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | PGR | P06401 | 4/20 | 0.70 |
| ▸ | AR | P10275 | 4/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.70 |
| ▸ | ATM | Q13315 | 3/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.70 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estradiol Propionate SCHEMBL28092621 | 0.94 | MAPT (0.91) | MAPTKMT2AMEN1THRBCYP3A4 | |
| Estradiol Dipropionate SCHEMBL30595753 | 0.92 | MAPT (1.00) | MAPTKMT2AMEN1THRBCYP3A4 | |
| Estradiol Dipropionate SCHEMBL11325156 | 0.92 | MAPT (1.00) | MAPTKMT2AMEN1THRBCYP3A4 | |
| Estradiol Dipropionate SCHEMBL23261681 | 0.92 | MAPT (1.00) | MAPTKMT2AMEN1THRBCYP3A4 | |
| Estradiol Dipropionate SCHEMBL348106 | 0.92 | MAPT (1.00) | MAPTKMT2AMEN1THRBCYP3A4 | |
| Estradiol Dipropionate SCHEMBL23262384 | 0.92 | MAPT (1.00) | MAPTKMT2AMEN1THRBCYP3A4 | |
| Estradiol Dipropionate SCHEMBL11698942 | 0.92 | MAPT (0.82) | MAPTKMT2AMEN1THRBCYP3A4 | |
| SCHEMBL547293 | 0.91 | LMNA (0.80) | MAPTKMT2AMEN1THRBCYP3A4 | |
| Estradiol Propionate SCHEMBL480992 | 0.90 | MAPT (1.00) | MAPTKMT2AMEN1THRBCYP3A4 | |
| Estradiol Propionate SCHEMBL30384276 | 0.90 | MAPT (1.00) | MAPTKMT2AMEN1THRBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007062198-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECHNOLOGY, INC. (US) | 2007-05-31 | — | — | WO | disclosed |