SCHEMBL5488841

SCHEMBL5488841

Cl[Si](Cl)(Cl)CCc1ccc(Oc2ccccc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.53
LTA4H P09960 8/20 0.52
EPHX2 P34913 4/20 0.47
SRD5A2 P31213 2/20 0.46
TSHR P16473 1/20 0.46
PLAAT3 P53816 2/20 0.45
PLAAT5 Q96KN8 2/20 0.45
PLAAT2 Q9NWW9 2/20 0.45
PLAAT4 Q9UL19 2/20 0.45
FFAR4 Q5NUL3 1/20 0.45
CES1 P23141 1/20 0.42
NR1H2 P55055 1/20 0.42
BAX Q07812 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL208903 0.81 TDP1 (0.52) TSHR
SCHEMBL19322270 0.81 LTA4H (0.67) FFAR1LTA4HEPHX2SRD5A2TSHR
SCHEMBL28724005 0.79 FFAR1 (0.64) FFAR1LTA4HEPHX2SRD5A2TSHR
SCHEMBL6532094 0.79 TDP1 (0.50) TSHR
SCHEMBL6848455 0.78 CA2 (0.38)
SCHEMBL5493502 0.78 FFAR1 (0.48) FFAR1TSHR
SCHEMBL16755611 0.78 LTA4H (0.69) FFAR1LTA4HEPHX2SRD5A2TSHR
SCHEMBL8497351 0.78 FFAR1 (0.58) FFAR1LTA4HEPHX2SRD5A2TSHR
SCHEMBL1082295 0.78 LTA4H (0.69) FFAR1LTA4HEPHX2SRD5A2TSHR
SCHEMBL19322272 0.77 FFAR1 (0.62) FFAR1LTA4HEPHX2SRD5A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed