Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5496438 | 0.80 | TGFBR1 (0.56) | TGFBR1GABRG2GABRB3GABRA5GRM5 | |
| SCHEMBL2044086 | 0.80 | TGFBR1 (0.49) | TGFBR1GABRG2GABRB3GABRA5THRB | |
| SCHEMBL2615267 | 0.80 | HSP90AA1 (0.57) | CRHR1HSP90AA1HSP90AB1TGFBR1CCR1 | |
| SCHEMBL17714135 | 0.76 | CRHR1 (0.41) | CRHR1HSP90AA1HSP90AB1HSD11B1MAPT | |
| SCHEMBL5907474 | 0.76 | TGFBR1 (0.46) | TGFBR1GRM5MAPK14 | |
| SCHEMBL27648484 | 0.75 | TGFBR1 (0.52) | TGFBR1CCR1CCR8METAP2MAPK14 | |
| SCHEMBL5492614 | 0.74 | TGFBR1 (0.58) | TGFBR1CCR1CCR8GRM5METAP2 | |
| SCHEMBL4338636 | 0.74 | HSD11B1 (0.47) | CRHR1HSP90AA1HSP90AB1ALPLHSD11B1 | |
| SCHEMBL8746755 | 0.74 | MAPT (0.49) | CRHR1HSP90AA1HSP90AB1ALPLHSD11B1 | |
| SCHEMBL28758711 | 0.73 | TGFBR1 (0.45) | TGFBR1CCR1CCR8GRM5METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276525-B2 | Osteogenesis-promotion enhancer and method of screening the same | NIPPON SHINYAKU CO. LTD. (JP) | 2007-10-02 | — | — | US | disclosed |
| US-20060183778-A1 | Osteogenesis-promotion enhancer and method of screening the same | JAPANESE FOUNDATION OF CANCER RESEARCH (JP) | 2006-08-17 | — | — | US | disclosed |
| EP-1632249-A1 | OSTEOGENESIS-PROMOTION ENHANCER AND METHOD OF SCREENING THE SAME | Nippon Shinyaku Co., Ltd. (JP) | 2006-03-08 | — | — | EP | disclosed |