Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5481359 | 0.92 | SIGMAR1 (0.58) | SIGMAR1MEN1KMT2AHRH3HRH1 | |
| SCHEMBL5480169 | 0.89 | SIGMAR1 (0.62) | SIGMAR1HRH1FAAH | |
| SCHEMBL5483514 | 0.87 | MEN1 (0.60) | SIGMAR1MEN1KMT2AFAAHMCHR1 | |
| SCHEMBL5490036 | 0.87 | MEN1 (0.55) | SIGMAR1MEN1KMT2AHRH2HRH1 | |
| SCHEMBL27564901 | 0.82 | SIGMAR1 (0.73) | SIGMAR1MEN1KMT2AFAAH | |
| SCHEMBL10502864 | 0.80 | SIGMAR1 (0.66) | SIGMAR1MEN1KMT2AHRH3HRH1 | |
| SCHEMBL5484678 | 0.80 | MEN1 (0.61) | SIGMAR1MEN1KMT2AHRH3FAAH | |
| SCHEMBL2931705 | 0.79 | AKR1C3 (0.65) | SIGMAR1MEN1KMT2AHRH3FAAH | |
| SCHEMBL5480249 | 0.78 | MEN1 (0.61) | SIGMAR1MEN1KMT2AFAAH | |
| SCHEMBL5486911 | 0.78 | NOTUM (0.50) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | claimed |
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | disclosed |