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Sugi Predict / Compounds / (Z)-1,2-Diphenylethene

(Z)-1,2-Diphenylethene

(Z)-1,2-Diphenylethene

SCHEMBL5489824

C(=Cc1ccccc1)c1ccccc1.CCCCCNCCCCC

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ SIGMAR1 Q99720 4/20 0.61
▸ EGFR P00533 1/20 0.57
▸ ALDH1A1 P00352 1/20 0.52
▸ TSHR P16473 1/20 0.52
▸ HDAC3 O15379 1/20 0.49
▸ LMNA P02545 1/20 0.46
▸ TDP1 Q9NUW8 2/20 0.45
▸ RELA Q04206 1/20 0.44
▸ HRH4 Q9H3N8 1/20 0.44
▸ HRH3 Q9Y5N1 1/20 0.44
▸ CHRM2 P08172 1/20 0.44
▸ NAAA Q02083 1/20 0.43
▸ TP53 P04637 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11031731 0.88 SIGMAR1 (0.53) SIGMAR1EGFRALDH1A1TSHRHDAC3
(Z)-1,2-Diphenylethene SCHEMBL28882092 0.87 RELA (0.54) EGFRHDAC3LMNATDP1RELA
SCHEMBL9779284 0.86 EGFR (0.52) SIGMAR1EGFRALDH1A1TSHRHDAC3
SCHEMBL11032819 0.86 EGFR (0.52) SIGMAR1EGFRALDH1A1TSHRHDAC3
SCHEMBL11034241 0.86 EGFR (0.52) SIGMAR1EGFRALDH1A1TSHRHDAC3
SCHEMBL11034504 0.86 EGFR (0.52) SIGMAR1EGFRALDH1A1TSHRHDAC3
SCHEMBL11033807 0.85 EGFR (0.51) SIGMAR1EGFRALDH1A1HDAC3LMNA
Dipentylamine SCHEMBL5492942 0.85 SIGMAR1 (0.58) SIGMAR1EGFRALDH1A1TSHRLMNA
Benzaldehyde SCHEMBL9879104 0.85 SIGMAR1 (0.58) SIGMAR1EGFRALDH1A1TSHRLMNA
Benzaldehyde SCHEMBL9746116 0.85 SIGMAR1 (0.58) SIGMAR1EGFRALDH1A1TSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7276627-B2 One pot sequential reactions and novel products produced thereby IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2007-10-02 — — US claimed
US-20060224017-A1 One pot sequential reactions and novel products produced thereby IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 2006-10-05 — — US claimed
US-7276627-B2 One pot sequential reactions and novel products produced thereby IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2007-10-02 — — US disclosed
US-7276627-B2 One pot sequential reactions and novel products produced thereby IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2007-10-02 — — US disclosed
US-20060224017-A1 One pot sequential reactions and novel products produced thereby IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 2006-10-05 — — US disclosed
US-20060224017-A1 One pot sequential reactions and novel products produced thereby IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 2006-10-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060224017-A1 One pot sequential reactions and novel products produced thereby PNMT, CYP1A1, TERT SIGMAR1 4347/4885EGFR 4305/4885ALDH1A1 602/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.