Hydrochloric Acid

Hydrochloric Acid

SCHEMBL548983

Cl.O=S(=O)(O)c1ccccc1

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.94
SMN1; SMN2 Q16637 1/20 0.94
POLB P06746 1/20 0.60
CYP2D6 P10635 1/20 0.60
HTR6 P50406 1/20 0.55
LMNA P02545 1/20 0.55
ALDH1A1 P00352 4/20 0.52
NT5E P21589 1/20 0.52
TDP1 Q9NUW8 3/20 0.50
HSD17B10 Q99714 2/20 0.50
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
CA12 O43570 1/20 0.50
CA3 P07451 1/20 0.50
CA4 P22748 1/20 0.50
CA6 P23280 1/20 0.50
CA5A P35218 1/20 0.50
CA7 P43166 1/20 0.50
PLA2G7 Q13093 1/20 0.50
CA9 Q16790 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11436653 1.00 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6HTR6
Hydrochloric Acid SCHEMBL11436657 1.00 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6HTR6
Hydrochloric Acid SCHEMBL10626880 0.97 TSHR (0.89) TSHRSMN1; SMN2POLBCYP2D6HTR6
SCHEMBL30812783 0.97 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6HTR6
SCHEMBL597672 0.97 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6HTR6
SCHEMBL3409457 0.97 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6HTR6
Benzene SCHEMBL9751882 0.97 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6HTR6
SCHEMBL30307036 0.97 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6HTR6
SCHEMBL2509 0.97 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6HTR6
SCHEMBL30671620 0.97 TSHR (1.00) TSHRSMN1; SMN2POLBCYP2D6HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 809 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4301750-A1 NOVEL SALT FORMS OF A 4H-PYRAN-4-ONE STRUCTURED CYP11A1 INHIBITOR Orion Corporation (FI) 2024-01-10 EP claimed
US-11833225-B2 Methods and compositions for efficient gene deletion CRISPR THERAPEUTICS AG (CH) 2023-12-05 US claimed
WO-2022184978-A1 NOVEL SALT FORMS OF A 4H-PYRAN-4-ONE STRUCTURED CYP11A1 INHIBITOR ORION CORPORATION (FI) 2022-09-09 WO claimed
CN-112080011-A Dendritic macromolecule quaternary ammonium salt compound and preparation method and application thereof 惠州卫生职业技术学院 2020-12-15 CN claimed
EP-3259294-B1 HIGH TEMPERATURE RESISTANT FOAMS COVESTRO DEUTSCHLAND AG (DE) 2019-12-18 EP claimed
CN-110498798-A A kind of microreactor series connection synthetic method of indoles anti-tumor drug molecule UNIV FUDAN 2019-11-26 CN claimed
CN-109438289-A The synthetic method of high-purity benzene sulfonic acid chloride 苏州华道生物药业股份有限公司 2019-03-08 CN claimed
CN-108863870-A A kind of preparation method of alkyl substituted benzene thiophenol 天津瑞岭化工有限公司 2018-11-23 CN claimed
US-20180312655-A1 FOAM MATERIALS RESISTANT TO HIGH TEMPERATURES BASF SE (DE) 2018-11-01 US claimed
CN-108440389-A 3,4,5-trihydroxy benzoic acid derivative and the preparation method and application thereof 山东大学 2018-08-24 CN claimed
EP-0342532-B1 PROCESS FOR THE PREPARATION OF 4-CHLORO-2-METHYL-5-NITRO-PHENOL Wella Aktiengesellschaft (DE) 1993-01-07 EP claimed
US-4880576-A HALOGENATION OF ACIDS, FORMAMIDE CATALYSTS BAYER AKTIENGESELLSCHAFT (DE) 1989-11-14 US claimed
US-4389521-A AROMATIC POLYAMIDE TEIJIN LIMITED (JP) 1983-06-21 US claimed
US-4317752-A POLYURETHANE FOAMS; INSULATION; CONSTRUCTION MATERIALS BLOUNT DAVID H 1982-03-02 US claimed
US-4280006-A Process for the production of polyisocyanate silicate plastics utilizing an alkali metal cellulose silicate condensation product BLOUNT DAVID H 1981-07-21 US claimed
US-4262108-A FIREPROOF CONSTRUCTION MATERIALS, INSULATION BLOUNT DAVID H 1981-04-14 US claimed
US-4153764-A Process for the production of polyisocyanate organic silicate solid/cellular solid product BLOUNT DAVID H 1979-05-08 US claimed
US-4105692-A Process for the preparation of benzenesulphonyl chloride BAYER AKTIENGESELLSCHAFT (DE) 1978-08-08 US claimed
US-4006186-A MULTISTAGE FROM A PHENYLSULFONYL CHLORIDE AND HYDRAZINE BAYER AKTIENGESELLSCHAFT (DT) 1977-02-01 US claimed
US-3981831-A REACTION OF ORGANIC POLYISOCYANATE WITH ALKALI METAL SILICATE OR SILICA SOL BAYER AKTIENGESELLSCHAFT (DT) 1976-09-21 US claimed