Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489852 | 1.00 | NOTUM (0.36) | NOTUMALDH1A1MAPTCYP4A11CA1 | |
| SCHEMBL5491918 | 0.79 | KDM4E (0.35) | ALDH1A1MAPTTDP1GAAHPGD | |
| SCHEMBL5491912 | 0.79 | KDM4E (0.35) | ALDH1A1MAPTTDP1GAAHPGD | |
| SCHEMBL5497277 | 0.72 | NOTUM (0.36) | NOTUMALDH1A1MAPTCYP4A11CA1 | |
| SCHEMBL5497269 | 0.72 | NOTUM (0.36) | NOTUMALDH1A1MAPTCYP4A11CA1 | |
| SCHEMBL9442337 | 0.69 | MAPT (0.43) | ALDH1A1MAPTCYP4A11CA1CA2 | |
| SCHEMBL8982280 | 0.68 | CA1 (0.45) | ALDH1A1MAPTCA1CA2TDP1 | |
| SCHEMBL2656656 | 0.68 | MGLL (0.48) | ALDH1A1MAPTTSHRNPC1MAPK1 | |
| SCHEMBL14469263 | 0.66 | LOXL2 (0.51) | ALDH1A1MAPTCYP4A11CA1CA2 | |
| SCHEMBL27316459 | 0.66 | ALDH1A1 (0.51) | ALDH1A1MAPTCYP4A11CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167377-A1 | Inhibitors of glycinamide ribonucleotide transformylase | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-07-19 | — | — | US | disclosed |
| EP-1495006-A4 | INHIBITORS OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE | SCRIPPS RESEARCH INST (US) | 2006-05-10 | — | — | EP | disclosed |
| EP-1495006-A1 | INHIBITORS OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE | The Scripps Research Institute (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087065-A1 | INHIBITORS OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167377-A1 | Inhibitors of glycinamide ribonucleotide transformylase | TYMS, NMT2, NMT1 | NOTUM 1491/4885ALDH1A1 726/4885MAPT 2783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.