Oxytetracycline

SCHEMBL5489972

CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@@](C)(O)[C@H]3[C@H](O)[C@@H]12.CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@@](C)(O)[C@H]3[C@H](O)[C@@H]12.Cl

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Oxytetracycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	TDP1	Q9NUW8	11/20	0.70

▸	KDM4E	B2RXH2	10/20	0.70

▸	MEN1	O00255	10/20	0.70

▸	KMT2A	Q03164	10/20	0.70

▸	MAPT	P10636	7/20	0.70

▸	USP2	O75604	7/20	0.70

▸	HPGD	P15428	6/20	0.70

▸	L3MBTL1	Q9Y468	6/20	0.70

▸	RECQL	P46063	6/20	0.70

▸	HSD17B10	Q99714	5/20	0.70

▸	ALDH1A1	P00352	4/20	0.70

▸	ALOX15	P16050	2/20	0.70

▸	THRB	P10828	5/20	0.69

▸	POLB	P06746	4/20	0.69

▸	HIF1A	Q16665	3/20	0.69

▸	GAA	P10253	1/20	0.69

▸	LMNA	P02545	2/20	0.68

▸	CYP2C9	P11712	1/20	0.68

▸	BRCA1	P38398	1/20	0.68

▸	NR1I2	O75469	2/20	0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Oxytetracycline SCHEMBL124996	1.00	TDP1 (0.70)	TDP1KDM4EMEN1KMT2AMAPT
Oxytetracycline SCHEMBL28245415	1.00	TDP1 (0.70)	TDP1KDM4EMEN1KMT2AMAPT
Oxytetracycline SCHEMBL29365107	1.00	TDP1 (0.70)	TDP1KDM4EMEN1KMT2AMAPT
Oxytetracycline SCHEMBL113193	1.00	TDP1 (0.70)	TDP1KDM4EMEN1KMT2AMAPT
Oxytetracycline SCHEMBL18918485	0.99	TDP1 (0.69)	TDP1KDM4EMEN1KMT2AMAPT
Oxytetracycline SCHEMBL28562487	0.99	TDP1 (0.69)	TDP1KDM4EMEN1KMT2AMAPT
Oxytetracycline SCHEMBL459700	0.99	TDP1 (0.69)	TDP1KDM4EMEN1KMT2AMAPT
Oxytetracycline SCHEMBL9128434	0.99	TDP1 (0.69)	TDP1KDM4EMEN1KMT2AMAPT
Oxytetracycline SCHEMBL13782519	0.99	TDP1 (0.70)	TDP1KDM4EMEN1KMT2AMAPT
Oxytetracycline SCHEMBL2614977	0.99	TDP1 (0.70)	TDP1KDM4EMEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2007062198-A1	METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY	ADVANCED CELL TECHNOLOGY, INC. (US)	2007-05-31	—	—	WO	disclosed