Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Oxytetracycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.70 |
| ▸ | MEN1 | O00255 | 9/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.70 |
| ▸ | USP2 | O75604 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | RECQL | P46063 | 5/20 | 0.70 |
| ▸ | THRB | P10828 | 4/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxytetracycline SCHEMBL2899 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL13782519 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL13782617 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL18048891 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL13782467 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL5507247 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL1292896 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL21133474 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL21133472 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL13782478 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0135657-B1 | ANTIBACTERIAL DRUGS AND/OR FEED CONCENTRATES | EGIS GYOGYSZERGYAR (HU) | 1989-12-27 | — | — | EP | claimed |
| US-20160039749-A1 | 11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS | PARATEK PHARMACEUTICALS, INC. | 2016-02-11 | — | — | US | disclosed |
| US-20160031802-A1 | 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS | PARATEK PHARMACEUTICALS, INC. | 2016-02-04 | — | — | US | disclosed |
| US-20160031802-A1 | 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS | PARATEK PHARMACEUTICALS, INC. | 2016-02-04 | — | — | US | disclosed |
| US-8481513-B2 | 3, 10, and 12a substituted tetracycline compounds | PARATEK PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481513-B2 | 3, 10, and 12a substituted tetracycline compounds | PARATEK PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8470804-B2 | 11a, 12-derivatives of tetracycline compounds | PARATEK PHARMACEUTICALS, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8293931-B2 | 7-N-substituted phenyl tetracycline compounds | TRUSTEES OF TUFTS COLLEGE (US) | 2012-10-23 | — | — | US | disclosed |
| US-8168810-B2 | 7-phenyl-substituted tetracycline compounds | TRUSTEES OF TUFTS COLLEGE (US) | 2012-05-01 | — | — | US | disclosed |
| US-20120101070-A1 | 11a, 12-Derivatives of Tetracycline Compounds | PARATEK PHARMACEUTICALS, INC. (US) | 2012-04-26 | — | — | US | disclosed |
| US-20090124583-A1 | 7-N-substituted phenyl tetracycline compounds | TRUSTEES OF TUFTS COLLEGE (US) | 2009-05-14 | — | — | US | disclosed |
| US-7521437-B2 | 7-phenyl-substituted tetracycline compounds | TRUSTEES OF TUFTS COLLEGE (US) | 2009-04-21 | — | — | US | disclosed |
| US-20080306032-A1 | 7-Phenyl-Substituted Tetracycline Compounds | PARATEK PHARMACEUTICALS, INC. | 2008-12-11 | — | — | US | disclosed |
| US-20070155708-A1 | e.g. 7-(4-fluorophenyl) sancycline; for treating tetracycline responsive states; antibiotic resistance; rickettsiae: pneumococci and Salmonella | TRUSTEES OF TUFTS COLLEGE (US) | 2007-07-05 | — | — | US | disclosed |
| US-20070155708-A1 | e.g. 7-(4-fluorophenyl) sancycline; for treating tetracycline responsive states; antibiotic resistance; rickettsiae: pneumococci and Salmonella | TRUSTEES OF TUFTS COLLEGE (US) | 2007-07-05 | — | — | US | disclosed |
| US-20030092684-A1 | Compositions and methods for treating hemorrhagic virus infections and other disorders | ANTIBODY SYSTEMS, INC. | 2003-05-15 | — | — | US | disclosed |
| US-20020077276-A1 | Compositions and methods for treating hemorrhagic virus infections and other disorders | ANTIBODY SYSTEMS, INC. | 2002-06-20 | — | — | US | disclosed |
| US-5120711-A | Of polymyxin B and chlorquinaldol; for treatment of mastitis or fungal infections | EGIS GYOGYSZERGYAR (HU) | 1992-06-09 | — | — | US | disclosed |
| US-4324799-A | Fungicidal thioglycolic acid anilides, processes for their manufacture and pesticidal compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-04-13 | — | — | US | disclosed |
| US-3980798-A | Dichloromaleic imides for fungicidal composition and method | CIBA-GEIGY CORPORATION (US) | 1976-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155708-A1 | e.g. 7-(4-fluorophenyl) sancycline; for treating tetracycline responsive states; antibiotic resistance; rickettsiae: pneumococci and Salmonella | RAB7A, RPS7, SHPRH | TDP1 3513/4885MEN1 2339/4885KMT2A 4633/4885 |
| US-20020077276-A1 | Compositions and methods for treating hemorrhagic virus infections and other disorders | IL1R1, TNF, IL1A | TDP1 1636/4885MEN1 2311/4885KMT2A 3996/4885 |
| US-20090124583-A1 | 7-N-substituted phenyl tetracycline compounds | HDAC7, CASP7, CYP3A7 | TDP1 1320/4885MEN1 3102/4885KMT2A 2846/4885 |
| US-20030092684-A1 | Compositions and methods for treating hemorrhagic virus infections and other disorders | CCL11, SSB, TNF | TDP1 1126/4885MEN1 2687/4885KMT2A 3218/4885 |
| US-20080306032-A1 | 7-Phenyl-Substituted Tetracycline Compounds | TCF7, TPR, CYP3A7 | TDP1 1835/4885MEN1 3188/4885KMT2A 2608/4885 |
| US-20120101070-A1 | 11a, 12-Derivatives of Tetracycline Compounds | TOP2A, DHFR, TET1 | TDP1 1441/4885MEN1 2527/4885KMT2A 1883/4885 |
| US-20160031802-A1 | 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS | MYC, TET3, MYCBP | TDP1 3702/4885MEN1 1030/4885KMT2A 796/4885 |
| US-20160039749-A1 | 11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS | TOP2A, DHFR, TET1 | TDP1 1441/4885MEN1 2527/4885KMT2A 1883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.