Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310507 | 0.75 | CHRM2 (0.46) | CHRM2CHRM3GPBAR1TACR1KCNH2 | |
| SCHEMBL16506294 | 0.74 | HSD11B1 (0.51) | NOTUMHSD11B1 | |
| SCHEMBL10532934 | 0.71 | KMO (0.43) | NOTUMGPBAR1 | |
| SCHEMBL29624981 | 0.71 | TSHR (0.59) | NOTUM | |
| SCHEMBL1920001 | 0.71 | TSHR (0.59) | NOTUM | |
| SCHEMBL24400223 | 0.71 | KMO (0.43) | NOTUMGPBAR1 | |
| SCHEMBL9526608 | 0.71 | NOTUM (0.46) | NOTUMGPBAR1 | |
| SCHEMBL30255650 | 0.71 | NOTUM (0.46) | NOTUMGPBAR1 | |
| SCHEMBL5498972 | 0.70 | TAS1R3 (0.60) | MEN1KMT2A | |
| SCHEMBL313146 | 0.70 | KIF11 (0.54) | NOTUMGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | disclosed |