SCHEMBL5491010

SCHEMBL5491010

O=C(Nc1ccccc1)c1ccccc1Oc1cccc2ccccc12

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 9/20 0.70
MEN1 O00255 7/20 0.70
LMNA P02545 3/20 0.70
MITF O75030 1/20 0.70
POLB P06746 1/20 0.70
L3MBTL1 Q9Y468 1/20 0.70
DEGS1 O15121 1/20 0.56
NPC1 O15118 1/20 0.55
RAB9A P51151 1/20 0.55
SGMS2 Q8NHU3 1/20 0.54
NR1H4 Q96RI1 1/20 0.53
MAPT P10636 2/20 0.53
HPGD P15428 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
HTT P42858 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
KCNK3 O14649 2/20 0.52
KCNK9 Q9NPC2 2/20 0.52
ALDH1A1 P00352 3/20 0.51
USP2 O75604 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL368228 0.82 DEGS1 (0.78) KMT2AMEN1LMNADEGS1NPC1
SCHEMBL31150345 0.82 DEGS1 (0.78) KMT2AMEN1LMNADEGS1NPC1
SCHEMBL3135970 0.81 NR4A1 (0.63) KMT2AMEN1LMNAMITFPOLB
SCHEMBL6408304 0.78 MEN1 (0.69) KMT2AMEN1LMNAMITFPOLB
SCHEMBL8052702 0.78 KMT2A (0.63) KMT2AMEN1LMNARAB9ASGMS2
SCHEMBL9352975 0.78 ALDH1A1 (0.54) KMT2AMEN1LMNAMITFPOLB
SCHEMBL15779051 0.77 BRAF (0.65) KMT2AMEN1LMNAMITFPOLB
SCHEMBL2466597 0.77 MEN1 (0.65) KMT2AMEN1LMNAMITFPOLB
SCHEMBL28949726 0.76 KMT2A (0.48) KMT2AMEN1LMNAMITFPOLB
SCHEMBL28578209 0.76 KMT2A (0.61) KMT2AMEN1LMNAMITFPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1328507-B1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS UNIV NEW YORK STATE RES FOUND (US) 2007-03-14 EP disclosed
CN-1249019-C Naphthylsalicylanilides as antimicrobial and antiinflammatory agents NEW YORK STATE UNIVERSITY RES (US) 2006-04-05 CN disclosed
CN-1249019-C Naphthylsalicylanilides as antimicrobial and antiinflammatory agents NEW YORK STATE UNIVERSITY RES (US) 2006-04-05 CN disclosed
US-6960553-B2 Heat-sensitive recording material MITSUBISHI PAPER MILLS LTD. (JP) 2005-11-01 US disclosed
CN-1468210-A Naphthylsalicylanilides as antimicrobial and antiinflammatory agents ŦԼ������ѧ�о������ 2004-01-14 CN disclosed
CN-1468210-A Naphthylsalicylanilides as antimicrobial and antiinflammatory agents ŦԼ������ѧ�о������ 2004-01-14 CN disclosed
US-20030186810-A1 Heat-sensitive recording material MITSUBISHI PAPER MILLS LTD. 2003-10-02 US disclosed
EP-1328507-A1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS The Research Foundation Of State University of New York (US) 2003-07-23 EP disclosed
EP-1328507-A1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS The Research Foundation Of State University of New York (US) 2003-07-23 EP disclosed
US-6407288-B1 AS ANTIBACTERIAL AGAINST GRAM NEGATIVE AND GRAM POSITIVE BACTERIA AND AS ANTIINFLAMMATORY AGENTS THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK 2002-06-18 US disclosed
US-6407288-B1 AS ANTIBACTERIAL AGAINST GRAM NEGATIVE AND GRAM POSITIVE BACTERIA AND AS ANTIINFLAMMATORY AGENTS THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK 2002-06-18 US disclosed
US-6407288-B1 AS ANTIBACTERIAL AGAINST GRAM NEGATIVE AND GRAM POSITIVE BACTERIA AND AS ANTIINFLAMMATORY AGENTS THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK 2002-06-18 US disclosed
US-20020065322-A1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE 2002-05-30 US disclosed
US-20020065322-A1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE 2002-05-30 US disclosed
WO-2002028819-A1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2002-04-11 WO disclosed
WO-2002028819-A1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2002-04-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020065322-A1 NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS PTGES3, FPR3, PTGS1 KMT2A 3534/4885MEN1 4531/4885LMNA 2986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.