Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3110457 | 0.80 | PIK3CA (0.50) | PIK3CACYP1A2TSHRACHEPIK3CD | |
| SCHEMBL11929763 | 0.76 | PIK3CA (0.47) | PIK3CACYP1A2TSHRPIK3CDPIK3CB | |
| SCHEMBL3106073 | 0.75 | PIK3CA (0.62) | PIK3CA | |
| SCHEMBL3112884 | 0.75 | PIK3CA (0.52) | PIK3CATSHRHSD17B10 | |
| SCHEMBL13848016 | 0.74 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CBPIK3R1MTOR | |
| SCHEMBL24920536 | 0.74 | ACHE (0.48) | PIK3CACYP1A2TSHRACHEPIK3CD | |
| SCHEMBL23299902 | 0.72 | NAPEPLD (0.43) | PIK3CACYP1A2PIK3CBALDH1A1 | |
| SCHEMBL11926315 | 0.71 | NAPEPLD (0.52) | PIK3CAMTORRAF1BRAFPIK3CG | |
| SCHEMBL11926312 | 0.71 | NAPEPLD (0.56) | PIK3CAMTORPIK3CG | |
| SCHEMBL11926353 | 0.69 | NAPEPLD (0.51) | PIK3CARAF1BRAFALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819341-A2 | IL-12 MODULATORY COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006053227-A2 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2006-05-18 | — | — | WO | disclosed |