Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TPH1 | P17752 | 2/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 4/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | CPB1 | P15086 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL5491744 | 1.00 | SLC7A5 (0.38) | SLC7A5CYP3A4CYP1A2TPH1CPB2 | |
| Histidine SCHEMBL27762881 | 0.87 | TPH1 (0.38) | SLC7A5CYP3A4CYP1A2TPH1CPB2 | |
| Histidine SCHEMBL3258 | 0.86 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2ALPIPKM | |
| Histidine SCHEMBL163443 | 0.86 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2ALPIPKM | |
| Histidine SCHEMBL3259 | 0.86 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2ALPIPKM | |
| Histidine SCHEMBL18824897 | 0.86 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2ALPIPKM | |
| Histidine SCHEMBL388563 | 0.86 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2ALPIPKM | |
| Histidine SCHEMBL163442 | 0.86 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2ALPIPKM | |
| Histidine SCHEMBL995910 | 0.86 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2ALPIPKM | |
| Histidine SCHEMBL8080341 | 0.86 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858538-A2 | MUCIN HYPERSECRETION INHIBITORS BASED ON THE STRUCTURE OF MANS AND METHODS OF USE | Biomarck Pharmaceuticals, Ltd. (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006078899-A2 | MUCIN HYPERSECRETION INHIBITORS BASED ON THE STRUCTURE OF MANS AND METHODS OF USE | BIOMARCK PHARMACEUTICALS, LTD. (US) | 2006-07-27 | — | — | WO | disclosed |