Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921406 | 0.86 | MAPT (0.46) | KMT2AMEN1SMN1; SMN2GAALMNA | |
| SCHEMBL22814361 | 0.82 | MAPK13 (0.50) | KMT2AMEN1SMN1; SMN2LMNAHTT | |
| SCHEMBL3371377 | 0.79 | MAPT (0.60) | KMT2AMEN1SMN1; SMN2GAALMNA | |
| SCHEMBL6355590 | 0.78 | MAPK14 (0.47) | KMT2AMEN1SMN1; SMN2GAALMNA | |
| SCHEMBL5492276 | 0.78 | MAPT (0.65) | KMT2AMEN1SMN1; SMN2GAALMNA | |
| SCHEMBL18591632 | 0.76 | RAPGEF4 (0.48) | KMT2AMEN1SMN1; SMN2NPSR1HTT | |
| SCHEMBL16481326 | 0.76 | ALDH1A1 (0.57) | SMN1; SMN2LMNAMAPTRAB9ANPC1 | |
| Benzene SCHEMBL7148507 | 0.75 | KMT2A (0.50) | KMT2AMEN1SMN1; SMN2GAANPSR1 | |
| SCHEMBL11219348 | 0.75 | MAPT (0.60) | KMT2AMEN1SMN1; SMN2GAALMNA | |
| SCHEMBL1155655 | 0.75 | ALDH1A1 (0.53) | KMT2AMEN1SMN1; SMN2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936607-B2 | 2,4,6-Triaminopyrimidines for the treatment of depression and/or anxiety | H. LUNOBECK A/S (DK) | 2005-08-30 | — | — | US | disclosed |