Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | UGT2B7 | P16662 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4302076 | 0.78 | MAPT (0.38) | CYP2D6MAPTKDM4ELMNAMGAM | |
| SCHEMBL1664773 | 0.78 | MAPT (0.38) | MAPTKDM4ELMNAMGAMGAA | |
| SCHEMBL14535008 | 0.78 | CTSK (0.35) | — | |
| SCHEMBL5497112 | 0.78 | ANPEP (0.34) | LMNAKMT2A | |
| SCHEMBL2912395 | 0.77 | CPA1 (0.45) | MAPTKDM4ELMNAMGAMGAA | |
| SCHEMBL1410099 | 0.77 | CPA1 (0.45) | MAPTKDM4ELMNAMGAMGAA | |
| SCHEMBL1228652 | 0.77 | CPA1 (0.45) | MAPTKDM4ELMNAMGAMGAA | |
| SCHEMBL29021009 | 0.77 | MAPT (0.37) | MAPTKDM4ELMNAMGAMGAA | |
| SCHEMBL232250 | 0.76 | CYP2D6 (0.46) | CYP2D6LMNAKMT2AMGAMGAA | |
| SCHEMBL5105701 | 0.76 | TSHR (0.41) | MAPTKDM4ELMNAKMT2AMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937032-B1 | SUBSTITUTED GAMMA AMINOBUTYRIC ACIDS AS PHARMACEUTICAL AGENTS | WARNER LAMBERT CO (US) | 2007-05-09 | — | — | EP | disclosed |
| US-6153650-A | TREATMENT OF EPILEPSY, FAINTNESS ATTACKS, HYPOKINESIA, CRANIAL DISORDERS, NEURODEGENERATIVE DISORDERS, DEPRESSION, ANXIETY, PANIC, PAIN, NEUROPATHOLOGICAL DISORDERS, INFLAMMATION, AND GASTROINTESTINAL DAMAGE. | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| EP-0937032-A1 | SUBSTITUTED GAMMA AMINOBUTYRIC ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998017627-A1 | SUBSTITUTED GAMMA AMINOBUTYRIC ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1998-04-30 | — | — | WO | disclosed |