Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912395 | 1.00 | CPA1 (0.45) | CPA1KDM4ELMNAMAPTMGAM | |
| SCHEMBL1410099 | 1.00 | CPA1 (0.45) | CPA1KDM4ELMNAMAPTMGAM | |
| SCHEMBL3121387 | 0.88 | KDM4E (0.39) | CPA1KDM4ELMNAMAPTMGAM | |
| SCHEMBL29021009 | 0.87 | MAPT (0.37) | CPA1KDM4ELMNAMAPTMGAM | |
| SCHEMBL29021054 | 0.84 | KDM4E (0.36) | CPA1KDM4ELMNAMAPTMGAM | |
| SCHEMBL3867987 | 0.84 | CPA1 (0.42) | CPA1KDM4ELMNAMAPTMGAM | |
| SCHEMBL17748406 | 0.83 | CPA1 (0.47) | CPA1LMNAMAPTALDH1A1TSHR | |
| SCHEMBL234997 | 0.82 | MGAM (0.46) | LMNAMGAMGAASIMGAM2 | |
| SCHEMBL1664773 | 0.82 | MAPT (0.38) | CPA1KDM4ELMNAMAPTMGAM | |
| SCHEMBL4302076 | 0.82 | MAPT (0.38) | CPA1KDM4ELMNAMAPTMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108997128-B | Preparation method of pregabalin intermediate 3-nitromethyl-5-ethyl methylhexanoate | 浙江工业大学 | 2021-02-02 | — | — | CN | claimed |
| CN-108997128-B | Preparation method of pregabalin intermediate 3-nitromethyl-5-ethyl methylhexanoate | 浙江工业大学 | 2021-02-02 | — | — | CN | disclosed |
| CN-106488906-B | β -SUBSTITUTED GAMMA-AMINOCARBOXYLIC ACIDS AND THEIR USE AS ANTHROMATIC AGENTS | 斯福瑞有限公司 | 2018-10-26 | — | — | CN | disclosed |
| EP-3154930-B1 | METHOD FOR THE PREPARATION OF BETA-SUBSTITUTED GAMMA-AMINO CARBOXYLIC ACIDS | SIEGFRIED LTD (CH) | 2018-04-18 | — | — | EP | disclosed |
| EP-3210667-A1 | MODULAR CONTINUOUS FLOW DEVICE | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-08-30 | — | — | EP | disclosed |
| US-9745249-B2 | Method for the preparation of beta-substituted gamma-amino carboxylic acids | SIEGFRIED LTD. (CH) | 2017-08-29 | — | — | US | disclosed |
| US-9745249-B2 | Method for the preparation of beta-substituted gamma-amino carboxylic acids | SIEGFRIED LTD. (CH) | 2017-08-29 | — | — | US | disclosed |
| US-9745249-B2 | Method for the preparation of beta-substituted gamma-amino carboxylic acids | SIEGFRIED LTD. (CH) | 2017-08-29 | — | — | US | disclosed |
| US-20170114003-A1 | METHOD FOR THE PREPARATION OF BETA-SUBSTITUTED GAMMA-AMINO CARBOXYLIC ACIDS | SIEGFRIED LTD. (CH) | 2017-04-27 | — | — | US | disclosed |
| US-20170114003-A1 | METHOD FOR THE PREPARATION OF BETA-SUBSTITUTED GAMMA-AMINO CARBOXYLIC ACIDS | SIEGFRIED LTD. (CH) | 2017-04-27 | — | — | US | disclosed |
| US-20070197827-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-08-23 | — | — | US | disclosed |
| US-20070191636-A1 | Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the synthesis of (S)-Pregabalin | TEVA PHARMACEUTICAL USA, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20070191636-A1 | Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the synthesis of (S)-Pregabalin | TEVA PHARMACEUTICAL USA, INC. | 2007-08-16 | — | — | US | disclosed |
| EP-1768950-A2 | PROCESS FOR MAKING (S)-PREGABALIN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-04-04 | — | — | EP | disclosed |
| EP-1768973-A1 | SUBSTITUTED QUINOLONES | AiCuris GmbH & Co. KG (DE) | 2007-04-04 | — | — | EP | disclosed |
| WO-2007035890-A1 | AN ASYMMETRIC SYNTHESIS OF ( S ) - ( + ) -3- (AMINOMETHYL) -5-METHYLHEXANOIC ACID | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-03-29 | — | — | WO | disclosed |
| WO-2007035789-A1 | CHIRAL 3-CARBAMOYLMETHYL-5-METHYL HEXANOIC ACIDS, KEY INTERMEDIATES FOR THE NEW SYNTHESIS OF (S)-PREGABALIN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-03-29 | — | — | WO | disclosed |
| US-20070066846-A1 | Process for making (S)-Pregabalin | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-03-22 | — | — | US | disclosed |
| WO-2006110783-A2 | PROCESS FOR MAKING (S)-PREGABALIN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-10-19 | — | — | WO | disclosed |
| WO-2006008046-A1 | SUBSTITUTED QUINOLONES | AICURIS GMBH & CO. KG (DE) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197827-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | RIMKLA, COASY, GABRE | CPA1 3694/4885KDM4E 1334/4885LMNA 4205/4885 |
| US-20170114003-A1 | METHOD FOR THE PREPARATION OF BETA-SUBSTITUTED GAMMA-AMINO CARBOXYLIC ACIDS | GLUL, GABRB2, GABRB1 | CPA1 2759/4885KDM4E 2153/4885LMNA 1678/4885 |
| US-20070066846-A1 | Process for making (S)-Pregabalin | GABRE, GABRA6, GABRA5 | CPA1 3500/4885KDM4E 1059/4885LMNA 3151/4885 |
| US-20070191636-A1 | Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the synthesis of (S)-Pregabalin | GABRE, GABRA5, GABRA6 | CPA1 2816/4885KDM4E 434/4885LMNA 4132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.