SCHEMBL5493606

SCHEMBL5493606

CCCCC(=O)O[C@]1(C(=O)C(O)O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3CC[C@@]21C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.56
MAPT P10636 3/20 0.56
CYP3A4 P08684 3/20 0.56
HIF1A Q16665 3/20 0.56
NR3C1 P04150 3/20 0.56
PGR P06401 3/20 0.56
KMT2A Q03164 2/20 0.56
NR1I2 O75469 2/20 0.56
HPGD P15428 1/20 0.56
MEN1 O00255 1/20 0.56
MLNR O43193 1/20 0.56
ADORA3 P0DMS8 1/20 0.56
HTT P42858 1/20 0.56
SLC6A3 Q01959 1/20 0.56
PDE4D Q08499 1/20 0.56
PDE3A Q14432 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
CYP19A1 P11511 7/20 0.49
USP2 O75604 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11822457 0.92 LMNA (0.58) LMNAMAPTCYP3A4HIF1ANR3C1
SCHEMBL9501753 0.87 LMNA (0.61) LMNAMAPTCYP3A4HIF1APGR
SCHEMBL4218580 0.85 LMNA (0.59) LMNAMAPTCYP3A4HIF1ANR3C1
SCHEMBL11806510 0.84 LMNA (0.57) LMNAMAPTCYP3A4HIF1ANR3C1
SCHEMBL4218584 0.84 LMNA (0.57) LMNAMAPTCYP3A4HIF1ANR3C1
SCHEMBL11567748 0.83 LMNA (0.58) LMNAMAPTCYP3A4HIF1ANR3C1
SCHEMBL4807382 0.82 LMNA (0.59) LMNAMAPTCYP3A4HIF1ANR3C1
SCHEMBL4210066 0.82 LMNA (0.61) LMNAMAPTCYP3A4HIF1ANR3C1
SCHEMBL3476071 0.82 LMNA (0.61) LMNAMAPTCYP3A4HIF1ANR3C1
SCHEMBL11582030 0.81 NR3C1 (0.61) LMNACYP3A4HIF1ANR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070021360-A1 Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase EPIGENESIS PHARMACEUTICALS, LLC 2007-01-25 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021360-A1 Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase RECQL, GSS, DDX17 LMNA 4087/4885MAPT 4848/4885CYP3A4 2529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.