Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | KLRK1 | P26718 | 3/20 | 0.38 |
| ▸ | MICA | Q29983 | 3/20 | 0.38 |
| ▸ | RAET1L | Q5VY80 | 3/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | MAX | P61244 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | APOB | P04114 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820684 | 0.81 | KDM4E (0.51) | BACE1SLC6A3SLC6A4 | |
| SCHEMBL10645473 | 0.77 | SLC6A3 (0.69) | BACE1SLC6A3SLC6A4CFTRKLRK1 | |
| SCHEMBL29979725 | 0.77 | SLC6A3 (0.69) | BACE1SLC6A3SLC6A4CFTRKLRK1 | |
| SCHEMBL4285343 | 0.76 | NOTUM (0.43) | CFTR | |
| SCHEMBL29917415 | 0.73 | SLC6A3 (0.52) | BACE1PTPN1SLC6A3SLC6A4CFTR | |
| SCHEMBL30755410 | 0.73 | BACE1 (0.44) | BACE1PTPN1SLC6A3SLC6A4CFTR | |
| SCHEMBL7041867 | 0.73 | BACE1 (0.44) | BACE1PTPN1SLC6A3SLC6A4CFTR | |
| SCHEMBL28825335 | 0.72 | KLRK1 (0.52) | BACE1KLRK1MICARAET1L | |
| SCHEMBL8728062 | 0.72 | SLC6A3 (0.50) | SLC6A3SLC6A4CFTRMYC | |
| SCHEMBL9556244 | 0.71 | SLC6A3 (0.41) | PTPN1SLC6A3SLC6A4CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304086-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2007-12-04 | — | — | US | claimed |