SCHEMBL5494133

SCHEMBL5494133

C=C(C)[Si](O[SiH](C)C)(c1ccccc1)c1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PAX8 Q06710 1/20 0.33
HPGD P15428 1/20 0.32
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9118568 0.76 PAX8 (0.34) PAX8HPGDESR1ESR2
SCHEMBL3404339 0.71 ESR1 (0.35) ESR1ESR2
SCHEMBL5701556 0.71 ESR1 (0.35) ESR1ESR2
SCHEMBL4610928 0.70 ESR1 (0.33) ESR1ESR2
SCHEMBL7900984 0.70 ESR1 (0.43) PAX8HPGDESR1ESR2
SCHEMBL94175 0.70 ESR1 (0.33) ESR1ESR2
SCHEMBL330426 0.70 ESR1 (0.33) ESR1ESR2
SCHEMBL5373908 0.69 TSHR (0.33)
SCHEMBL5377943 0.69 TSHR (0.33)
SCHEMBL297373 0.69 ESR1 (0.37) ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7279507-B2 Contact lenses COOPERVISION INTERNATIONAL HOLDING COMPANY, LP (BB) 2007-10-09 US claimed
EP-1095076-A4 INTERPENETRATING POLYMER NETWORK HYDROPHILIC HYDROGELS FOR CONTACT LENS SUNSOFT CORP (US) 2002-11-06 EP claimed
US-20010044482-A1 Interpenetrating polymer network hydrophilic hydrogels for contact lens COOPERVISION INTERNATIONAL LIMITED (GB) 2001-11-22 US claimed
EP-1095076-A1 INTERPENETRATING POLYMER NETWORK HYDROPHILIC HYDROGELS FOR CONTACT LENS Sunsoft Corporation (US) 2001-05-02 EP claimed
WO-2000002937-A1 INTERPENETRATING POLYMER NETWORK HYDROPHILIC HYDROGELS FOR CONTACT LENS SUNSOFT CORPORATION (US) 2000-01-20 WO claimed
US-7279507-B2 Contact lenses COOPERVISION INTERNATIONAL HOLDING COMPANY, LP (BB) 2007-10-09 US disclosed
US-20050148682-A1 Interpenetrating polymer network hydrophilic hydrogels for contact lens COOPERVISION INTERNATIONAL LIMITED (GB) 2005-07-07 US disclosed
EP-1095076-A4 INTERPENETRATING POLYMER NETWORK HYDROPHILIC HYDROGELS FOR CONTACT LENS SUNSOFT CORP (US) 2002-11-06 EP disclosed
US-20010044482-A1 Interpenetrating polymer network hydrophilic hydrogels for contact lens COOPERVISION INTERNATIONAL LIMITED (GB) 2001-11-22 US disclosed
EP-1095076-A1 INTERPENETRATING POLYMER NETWORK HYDROPHILIC HYDROGELS FOR CONTACT LENS Sunsoft Corporation (US) 2001-05-02 EP disclosed
WO-2000002937-A1 INTERPENETRATING POLYMER NETWORK HYDROPHILIC HYDROGELS FOR CONTACT LENS SUNSOFT CORPORATION (US) 2000-01-20 WO disclosed