SCHEMBL5377943

SCHEMBL5377943

C=C(c1ccccc1)[Si](C)(O[SiH](C)C)C(=C)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.33
DAO P14920 1/20 0.33
NAPRT Q6XQN6 1/20 0.33
MAPT P10636 2/20 0.32
LMNA P02545 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
XBP1 P17861 1/20 0.32
ATM Q13315 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
ALDH1A1 P00352 1/20 0.32
ELANE P08246 1/20 0.31
F2 P00734 1/20 0.30
EGFR P00533 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5373908 0.85 TSHR (0.33) TSHRDAONAPRTMAPTLMNA
SCHEMBL28206375 0.76 PAX8 (0.35) TSHRDAONAPRTMAPTLMNA
SCHEMBL23045171 0.72 ATM (0.40) TSHRDAONAPRTMAPTLMNA
SCHEMBL8733750 0.69 TSHR (0.33) TSHRDAONAPRTMAPTLMNA
SCHEMBL5494133 0.69 PAX8 (0.33)
SCHEMBL11654664 0.69 MAOA (0.39) TSHRDAONAPRTMAPTLMNA
SCHEMBL1408930 0.67 TSHR (0.41) TSHRDAONAPRTMAPTLMNA
SCHEMBL27788524 0.65 TSHR (0.46) TSHRDAONAPRTMAPTLMNA
SCHEMBL297373 0.64 ESR1 (0.37)
SCHEMBL9763687 0.64 ESR1 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2007302721-A SILOXANE DERIVATIVE AND SILOXANE DERIVATIVE-COATING INORGANIC OXIDE TOKYO INSTITUTE OF TECHNOLOGY 2007-11-22 JP disclosed