Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3803922 | 0.93 | KMT2A (0.67) | KMT2AALDH1A1LMNACES2POLB | |
| SCHEMBL29544409 | 0.93 | KMT2A (0.67) | KMT2AALDH1A1LMNACES2POLB | |
| SCHEMBL7285749 | 0.80 | ALDH1A1 (0.48) | KMT2AALDH1A1CES2POLBMAPT | |
| SCHEMBL45190 | 0.80 | ALDH1A1 (0.62) | KMT2AALDH1A1LMNAPOLBMAPT | |
| SCHEMBL5341177 | 0.79 | CES2 (0.63) | KMT2AALDH1A1CES2POLBMAPT | |
| SCHEMBL6398309 | 0.79 | KMT2A (0.71) | KMT2AALDH1A1LMNAPOLBMAPT | |
| SCHEMBL1176899 | 0.79 | CTSD (0.63) | KMT2AALDH1A1LMNACES2POLB | |
| SCHEMBL114077 | 0.78 | KMT2A (0.65) | KMT2AALDH1A1LMNAPOLBTDP1 | |
| SCHEMBL11427017 | 0.78 | CES2 (0.58) | KMT2AALDH1A1LMNACES2POLB | |
| SCHEMBL503450 | 0.78 | CES2 (0.66) | KMT2AALDH1A1CES2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070160981-A1 | VIRAL PROTEASE | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070160981-A1 | VIRAL PROTEASE | XPNPEP1, PREP, XPNPEP2 | KMT2A 4176/4885ALDH1A1 4585/4885LMNA 532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.