SCHEMBL5494529

SCHEMBL5494529

CNC(=O)Oc1ccc(OC(F)(F)F)cc1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 2/20 0.53
L3MBTL1 Q9Y468 1/20 0.51
TRPV1 Q8NER1 3/20 0.45
POLB P06746 1/20 0.45
MAPT P10636 1/20 0.44
KMT2A Q03164 1/20 0.44
GAA P10253 1/20 0.44
HDAC3 O15379 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC2 Q92769 1/20 0.43
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
KIF11 P52732 1/20 0.42
NR1H4 Q96RI1 1/20 0.42
ALDH1A1 P00352 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12893245 0.84 ALDH1A1 (0.51) MAPTKMT2AGAAALDH1A1
SCHEMBL27647263 0.82 TP53 (0.52) EPHX2L3MBTL1TRPV1POLBMAPT
SCHEMBL11063357 0.81 KIF11 (0.54) EPHX2TRPV1KIF11ALDH1A1
SCHEMBL8471520 0.79 EPHX2 (0.50) EPHX2L3MBTL1TRPV1POLBMAPT
SCHEMBL3960405 0.79 LMNA (0.57) EPHX2L3MBTL1TRPV1POLBMAPT
SCHEMBL6924040 0.79 ALDH1A1 (0.51) MAPTGAAALDH1A1
SCHEMBL23493346 0.78 EPHX2 (0.57) EPHX2L3MBTL1TRPV1POLBMAPT
SCHEMBL10339425 0.78 EPHX2 (0.57) EPHX2TRPV1POLBMAPTKMT2A
SCHEMBL2208745 0.78 HPGD (0.63) EPHX2L3MBTL1TRPV1HDAC3HDAC1
SCHEMBL9326191 0.76 SMN1; SMN2 (0.59) GAAHDAC3HDAC1HDAC2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109704994-A A kind of improved method synthesizing indoxacarb intermediate chloroformyl [4- (trifluoromethoxy) phenyl] methyl carbamate 山东华阳农药化工集团有限公司 2019-05-03 CN claimed
CN-109535036-A A kind of synthetic method of indoxacarb intermediate chloroformyl [4- (trifluoromethoxy) phenyl] methyl carbamate 山东华阳农药化工集团有限公司 2019-03-29 CN claimed
CN-103910653-B The preparation method of chlorocarbonyl [4-(trifluoromethoxy) phenyl] methyl carbamate JINGBO AGROCHEMICALS TECHNOLOGY Co.,Ltd. (CN) 2016-05-25 CN claimed
CN-110511217-B Catalyst for catalyzing synthesis of indoxacarb key intermediate and application thereof 京博农化科技有限公司 2022-01-28 CN disclosed
CN-109535036-B Synthetic method of indoxacarb intermediate methyl chloroformyl [4- (trifluoromethoxy) phenyl ] carbamate 山东华阳农药化工集团有限公司 2021-05-25 CN disclosed
CN-107043360-B A kind of indoxacarb method for producing insecticide 京博农化科技股份有限公司 2019-07-12 CN disclosed
CN-109704994-A A kind of improved method synthesizing indoxacarb intermediate chloroformyl [4- (trifluoromethoxy) phenyl] methyl carbamate 山东华阳农药化工集团有限公司 2019-05-03 CN disclosed
CN-109704994-A A kind of improved method synthesizing indoxacarb intermediate chloroformyl [4- (trifluoromethoxy) phenyl] methyl carbamate 山东华阳农药化工集团有限公司 2019-05-03 CN disclosed
CN-109704994-A A kind of improved method synthesizing indoxacarb intermediate chloroformyl [4- (trifluoromethoxy) phenyl] methyl carbamate 山东华阳农药化工集团有限公司 2019-05-03 CN disclosed
CN-109535036-A A kind of synthetic method of indoxacarb intermediate chloroformyl [4- (trifluoromethoxy) phenyl] methyl carbamate 山东华阳农药化工集团有限公司 2019-03-29 CN disclosed
CN-109535036-A A kind of synthetic method of indoxacarb intermediate chloroformyl [4- (trifluoromethoxy) phenyl] methyl carbamate 山东华阳农药化工集团有限公司 2019-03-29 CN disclosed
EP-1357107-A1 Indanones and carbamate, and their use in the preparation of arthropodicial oxadiazines E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-10-29 EP disclosed
EP-0756594-B1 PREPARATION OF ARTHROPODICIDAL OXADIAZINES DU PONT (US) 2002-03-13 EP disclosed
US-6232489-B1 RACEMIC MIXTURES, ENANTIOMORPHS E. I. DU PONT DE NEMOURS AND COMPANY 2001-05-15 US disclosed
EP-1048647-A1 N-Chlorocarbonyl-carbamate derivative and its use in the preparation of arthropodicidal oxadiazines E.I. DU PONT DE NEMOURS AND COMPANY (US) 2000-11-02 EP disclosed
US-6080856-A Preparation of arthropodicidal oxadiazines E. I. DU PONT NEMOURS AND COMPANY (US) 2000-06-27 US disclosed
US-6018071-A Preparation of arthropodicidal ozadiazines E. I. DU PONT DE NEMOURS AND COMPANY (US) 2000-01-25 US disclosed
US-5869657-A Preparation of arthropodicidal oxadiazines E. I. DU PONT DE NEMOURS AND COMPANY (US) 1999-02-09 US disclosed
EP-0756594-A1 PREPARATION OF ARTHROPODICIDAL OXADIAZINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-02-05 EP disclosed
WO-1995029171-A1 PREPARATION OF ARTHROPODICIDAL OXADIAZINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-11-02 WO disclosed