Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 6/20 | 0.52 |
| ▸ | CA2 | P00918 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12893245 | 0.91 | ALDH1A1 (0.51) | SMN1; SMN2GAAALDH1A1HTTPLK1 | |
| SCHEMBL12793824 | 0.88 | PKM (0.63) | SMN1; SMN2GAAALDH1A1HTTPLK1 | |
| SCHEMBL28097321 | 0.83 | ALDH1A1 (0.48) | SMN1; SMN2GAAALDH1A1HTTPLK1 | |
| SCHEMBL27513052 | 0.83 | KDM4E (0.53) | SMN1; SMN2GAAALDH1A1HTTCA1 | |
| SCHEMBL2182880 | 0.83 | LMNA (0.59) | SMN1; SMN2GAAALDH1A1NPC1RAB9A | |
| SCHEMBL6924040 | 0.81 | ALDH1A1 (0.51) | SMN1; SMN2GAAALDH1A1NPC1RAB9A | |
| SCHEMBL2540440 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2GAAALDH1A1HTTNPC1 | |
| SCHEMBL20820013 | 0.81 | MGLL (0.54) | SMN1; SMN2GAAALDH1A1NPC1RAB9A | |
| SCHEMBL11599136 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2GAAALDH1A1HTTNPC1 | |
| SCHEMBL188010 | 0.81 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1NPC1RAB9ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853681-A | Preparation method of pyrimidine heterocyclic guanyl formate compound | 南京工业大学 | 2022-08-05 | — | — | CN | disclosed |
| US-9446139-B2 | Polymer-based compositions and conjugates of HIV entry inhibitors | NEKTAR THERAPEUTICS (US) | 2016-09-20 | — | — | US | disclosed |
| US-8580919-B2 | Polymer conjugates of GLP-1 | NEKTAR THERAPEUTICS (US) | 2013-11-12 | — | — | US | disclosed |
| US-8569267-B2 | Tetracyclic tetrahydrofuran derivatives containing cyclic amine side chain | JANSSEN PHARMACEUTICA, NV (BE) | 2013-10-29 | — | — | US | disclosed |
| US-20130096258-A1 | POLYMER CONJUGATES OF GLP-1 | NEKTAR THERAPEUTICS (US) | 2013-04-18 | — | — | US | disclosed |
| US-7879953-B2 | Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2011-02-01 | — | — | US | disclosed |
| US-7879953-B2 | Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2011-02-01 | — | — | US | disclosed |
| US-20100297211-A1 | BIOBENEFICIAL POLYAMIDE/POLYETHYLENE GLYCOL POLYMERS FOR USE WITH DRUG ELUTING STENTS | PACETTI STEPHEN D | 2010-11-25 | — | — | US | disclosed |
| US-20100297211-A1 | BIOBENEFICIAL POLYAMIDE/POLYETHYLENE GLYCOL POLYMERS FOR USE WITH DRUG ELUTING STENTS | PACETTI STEPHEN D | 2010-11-25 | — | — | US | disclosed |
| US-7786249-B2 | Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2010-08-31 | — | — | US | disclosed |
| US-20090012606-A1 | BIOBENEFICIAL POLYAMIDE/POLYETHYLENE GLYCOL POLYMERS FOR USE WITH DRUG ELUTING STENTS | PACETTI STEPHEN D | 2009-01-08 | — | — | US | disclosed |
| US-20090012606-A1 | BIOBENEFICIAL POLYAMIDE/POLYETHYLENE GLYCOL POLYMERS FOR USE WITH DRUG ELUTING STENTS | PACETTI STEPHEN D | 2009-01-08 | — | — | US | disclosed |
| US-20090012243-A1 | BIOBENEFICIAL POLYAMIDE/POLYETHYLENE GLYCOL POLYMERS FOR USE WITH DRUG ELUTING STENTS | PACETTI STEPHEN D | 2009-01-08 | — | — | US | disclosed |
| US-20090012243-A1 | BIOBENEFICIAL POLYAMIDE/POLYETHYLENE GLYCOL POLYMERS FOR USE WITH DRUG ELUTING STENTS | PACETTI STEPHEN D | 2009-01-08 | — | — | US | disclosed |
| US-20080262076-A1 | Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain | JANSSEN PHARMACEUTICA, NV (BE) | 2008-10-23 | — | — | US | disclosed |
| US-20080262076-A1 | Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain | JANSSEN PHARMACEUTICA, NV (BE) | 2008-10-23 | — | — | US | disclosed |
| US-7435788-B2 | Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435788-B2 | Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-7365196-B2 | Sulphonamido-substituted bridged bicycloalkyl derivatives | MERCK SHARP & DOHME LTD. (GB) | 2008-04-29 | — | — | US | disclosed |
| US-5365691-A | Methods and agents for combating cockroaches | BAYER AKTIENGESELLSCHAFT (DE) | 1994-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096258-A1 | POLYMER CONJUGATES OF GLP-1 | GLP1R, GIPR, NGLY1 | SMN1; SMN2 2005/4885GAA 1701/4885ALDH1A1 2730/4885 |
| US-20080262076-A1 | Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain | HTR2C, HTR2A, HTR5A | SMN1; SMN2 1902/4885GAA 2907/4885ALDH1A1 848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.