Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.35 |
| ▸ | CPN1 | P15169 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 3/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17029988 | 0.80 | GABRR1 (0.35) | FOLH1ENPEP | |
| SCHEMBL5415497 | 0.76 | CPB2 (0.44) | CPB2CPN1ACEFOLH1MME | |
| SCHEMBL17030026 | 0.73 | CYP2C19 (0.42) | — | |
| SCHEMBL17029982 | 0.72 | NOS3 (0.30) | — | |
| SCHEMBL17029980 | 0.70 | CYP1A2 (0.37) | FOLH1 | |
| SCHEMBL17029967 | 0.69 | — | — | |
| SCHEMBL2231293 | 0.69 | CPB2 (0.35) | CPB2CPN1FOLH1 | |
| SCHEMBL17030086 | 0.68 | TSHR (0.39) | THRBBLM | |
| SCHEMBL17029987 | 0.67 | — | — | |
| SCHEMBL17030203 | 0.67 | MTNR1A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9512172-B2 | Ethanol dependence of alpha1 antitrypsin C-terminal Lys truncation by basic carboxypeptidases | BAXALTA INCORPORATED (IL) | 2016-12-06 | — | — | US | disclosed |
| US-20140309176-A1 | ETHANOL DEPENDENCE OF ALPHA1 ANTITRYPSIN C-TERMINAL LYS TRUNCATION BY BASIC CARBOXYPEPTIDASES | BAXALTA INCORPORATED | 2014-10-16 | — | — | US | disclosed |
| US-8772240-B2 | Ethanol dependence of alpha1 antitrypsin C-terminal lys truncation by basic carboxypeptidases | BAXTER INTERNATIONAL INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20070274976-A1 | ETHANOL DEPENDENCE OF ALPHA1 ANTITRYPSIN C-TERMINAL LYS TRUNCATION BY BASIC CARBOXYPEPTIDASES | BAXALTA INCORPORATED | 2007-11-29 | — | — | US | disclosed |