Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 4/20 | 0.42 |
| ▸ | POLQ | O75417 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495693 | 0.83 | MKNK1 (0.46) | KCNH2ATMPOLQMKNK1MKNK2 | |
| SCHEMBL4316571 | 0.77 | PIK3CD (0.43) | PIK3CDPIK3CATDO2HSP90AA1PARP1 | |
| SCHEMBL7259314 | 0.74 | BCAT2 (0.57) | MKNK1MKNK2 | |
| SCHEMBL31031995 | 0.72 | PIK3CD (0.47) | POLQMKNK1MKNK2PIK3CDPIK3CA | |
| SCHEMBL27893740 | 0.70 | PIK3CD (0.54) | MKNK1MKNK2PIK3CDPIK3CATDO2 | |
| SCHEMBL4316563 | 0.70 | PIK3CD (0.43) | MKNK2PIK3CDPIK3CATDO2PARP1 | |
| SCHEMBL3698508 | 0.68 | MYC (0.44) | KCNH2 | |
| SCHEMBL5495689 | 0.67 | JAK2 (0.63) | AREGFR | |
| SCHEMBL4325902 | 0.67 | PIK3CD (0.41) | MKNK1MKNK2PIK3CDPIK3CATDO2 | |
| SCHEMBL24782968 | 0.67 | EGFR (0.68) | PIK3CDPIK3CATDO2AREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | disclosed |