Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27422387 | 0.85 | GNE (0.60) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL29432737 | 0.83 | SCN9A (0.47) | KCNK3KCNK9SMN1; SMN2GNEMAPK1 | |
| SCHEMBL29289680 | 0.83 | NPC1 (0.50) | L3MBTL1NPC1RAB9ATDP1HTR2C | |
| SCHEMBL31098498 | 0.83 | NPC1 (0.50) | L3MBTL1NPC1RAB9ATDP1HTR2C | |
| SCHEMBL30911663 | 0.81 | RAB9A (0.50) | NPC1RAB9AHTR2CALDH1A1SMN1; SMN2 | |
| SCHEMBL30911660 | 0.81 | RAB9A (0.50) | NPC1RAB9AHTR2CALDH1A1SMN1; SMN2 | |
| SCHEMBL1554586 | 0.81 | RAB9A (0.50) | NPC1RAB9AHTR2CALDH1A1SMN1; SMN2 | |
| SCHEMBL947448 | 0.81 | HTR2C (0.54) | NPC1RAB9AHTR2CALDH1A1KDM4E | |
| SCHEMBL3239132 | 0.78 | HTR2C (0.54) | NPC1RAB9AHTR2CALDH1A1KMT2A | |
| SCHEMBL30149935 | 0.78 | RAB9A (0.52) | NPC1RAB9AHTR2CALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740574-A2 | 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES | Otsuka Pharmaceutical Company, Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105778-A2 | 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-11-10 | — | — | WO | disclosed |