Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH2 | P05091 | 20/20 | 1.00 |
| ▸ | MAOA | P21397 | 12/20 | 1.00 |
| ▸ | MAOB | P27338 | 12/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498133 | 0.92 | ALDH2 (0.89) | ALDH2MAOAMAOB | |
| SCHEMBL4679869 | 0.91 | ALDH2 (1.00) | ALDH2MAOAMAOB | |
| SCHEMBL4684115 | 0.91 | ALDH2 (1.00) | ALDH2MAOAMAOB | |
| SCHEMBL4686444 | 0.91 | ALDH2 (1.00) | ALDH2MAOAMAOB | |
| SCHEMBL25225097 | 0.90 | ALDH2 (0.82) | ALDH2MAOAMAOB | |
| SCHEMBL5492489 | 0.89 | ALDH2 (1.00) | ALDH2MAOAMAOB | |
| SCHEMBL740753 | 0.89 | ALDH2 (0.80) | ALDH2MAOAMAOB | |
| SCHEMBL1701152 | 0.89 | ALDH2 (1.00) | ALDH2MAOAMAOB | |
| SCHEMBL25223427 | 0.89 | ALDH2 (0.81) | ALDH2MAOAMAOB | |
| SCHEMBL4684681 | 0.88 | ALDH2 (1.00) | ALDH2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270332-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | VALLEE BERT L | 2007-11-22 | — | — | US | disclosed |
| EP-1077697-B1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | ENDOWMENT FOR RES IN HUMAN BIO (US) | 2006-07-19 | — | — | EP | disclosed |
| EP-1645272-A2 | Daidzin derivatives for the treatment of alcohol dependence or alcohol abuse | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 2006-04-12 | — | — | EP | disclosed |
| EP-1077697-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| US-6121010-A | SCREENING FOR COMPOUNDS WHICH REDUCE ALCOHOL (ETHANOL) CONSUMPTION BY DETERMINING EFFECTIVENESS FOR INHIBITING ALDEHYDE DEHYDROGENASE ACTIVITY ON ALDEHYDES DERIVED FROM SUBSTRATES OF MONOAMINE OXIDASE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999058124-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 1999-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270332-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | ADH1A, ADH5, ADH1C | ALDH2 16/4885MAOA 53/4885MAOB 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.