Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.60 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TACR3 | P29371 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | TACR2 | P21452 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18075841 | 0.84 | DHODH (0.51) | DHODHPDE10AMEN1KMT2AL3MBTL1 | |
| SCHEMBL18075813 | 0.83 | PDE10A (0.61) | DHODHPDE10ALMNATSHRTACR3 | |
| SCHEMBL8794990 | 0.82 | DHODH (0.51) | DHODHPDE10ALMNATSHRTACR3 | |
| SCHEMBL9502231 | 0.81 | DHODH (0.67) | DHODH | |
| SCHEMBL5183047 | 0.79 | POLB (0.55) | PDE10ALMNATSHRMEN1KMT2A | |
| SCHEMBL4729382 | 0.79 | ERN1 (0.54) | DHODHPDE10ALMNAMEN1KMT2A | |
| SCHEMBL9505833 | 0.79 | DHODH (0.50) | DHODHPDE10ALMNATSHRTACR3 | |
| Water SCHEMBL8130350 | 0.78 | POLB (0.53) | PDE10ALMNATSHRMEN1KMT2A | |
| SCHEMBL3434573 | 0.76 | DHODH (0.66) | DHODHPDE10ALMNATSHRMEN1 | |
| SCHEMBL8794864 | 0.76 | KDM4E (0.50) | DHODHPDE10ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017676-B1 | METHOD FOR THE SYNTHESIS OF QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM CORP (US) | 2007-02-14 | — | — | EP | claimed |