Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 14/20 | 0.66 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3886802 | 0.90 | ICMT (0.62) | ICMTSERPINE1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4941452 | 0.83 | ICMT (0.70) | ICMTSERPINE1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3861443 | 0.81 | ICMT (0.67) | ICMTSERPINE1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12572685 | 0.79 | ICMT (0.70) | ICMTSERPINE1LMNA | |
| SCHEMBL9030278 | 0.77 | LMNA (0.61) | CYP1A2CYP2C9CYP2C19HTTNPSR1 | |
| SCHEMBL5572599 | 0.75 | SERPINE1 (0.60) | ICMTSERPINE1LMNA | |
| SCHEMBL3237157 | 0.70 | MAPT (0.48) | — | |
| SCHEMBL4940403 | 0.70 | ICMT (0.53) | ICMT | |
| SCHEMBL2490511 | 0.70 | LMNA (0.59) | LMNA | |
| SCHEMBL27768465 | 0.70 | PLA2G2A (0.58) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397130-B1 | SUBSTITUTED INDOLE ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | WYETH CORP (US) | 2007-07-25 | — | — | EP | claimed |